Names & Taxonomy
- Uniprot ID:
- Q9UN19
- Entry Name:
- DAPP1_HUMAN
- Status:
- reviewed
- Protein Names:
- Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa)
- Gene Names:
- DAPP1 BAM32 HSPC066
- Gene Names Orf:
- HSPC066
- Gene Names Primary:
- DAPP1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 280
- Sequence:
- MGRAELLEGKMSTQDPSDLWSRSDGEAELLQDLGWYHGNLTRHAAEALLLSNGCDGSYLLRDSNETTGLYSLSVRAKDSVKHFHVEYTGYSFKFGFNEFSSLKDFVKHFANQPLIGSETGTLMVLKHPYPRKVEEPSIYESVRVHTAMQTGRTEDDLVPTAPSLGTKEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVNCFCLVFPFRTFYLCAKTGVEADEWIKILRWKLSQIRKQLNQGEGTIRSRSFIFK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.
- Gene Ontology Go:
- cytosol
plasma membrane
phosphatidylinositol-3,4,5-trisphosphate binding
phosphatidylinositol-3,4-bisphosphate binding
phospholipid binding
protein dephosphorylation
signal transduction - Gene Ontology Biological Process:
- protein dephosphorylation
signal transduction - Gene Ontology Molecular Function:
- phosphatidylinositol-3,4,5-trisphosphate binding
phosphatidylinositol-3,4-bisphosphate binding
phospholipid binding - Gene Ontology Cellular Component:
- cytosol
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Cytoplasm
Membrane
Phosphoprotein
Reference proteome
SH2 domain - Interacts With:
- O95704; Q8TBZ3