Names & Taxonomy

Uniprot ID:
Q9ULX7
Entry Name:
CAH14_HUMAN
Status:
reviewed
Protein Names:
Carbonic anhydrase 14 (EC 4.2.1.1) (Carbonate dehydratase XIV) (Carbonic anhydrase XIV) (CA-XIV)
Gene Names:
CA14 UNQ690/PRO1335
Gene Names Orf:
UNQ690/PRO1335
Gene Names Primary:
CA14
Organism:
Homo sapiens (Human)

Structure

Length:
337
Sequence:
MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYPECGNNAQSPIDIQTDSVTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPSTLYLGGLPRKYVAAQLHLHWGQKGSPGGSEHQINSEATFAELHIVHYDSDSYDSLSEAAERPQGLAVLGILIEVGETKNIAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQLGQYFRYNGSLTTPPCYQSVLWTVFYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGEMLSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Reversible hydration of carbon dioxide.
Catalytic Activity:
H(2)CO(3) = CO(2) + H(2)O.
Cofactor:
COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=7.9 mM for CO(2)
Enzyme Regulation:
ENZYME REGULATION: Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide (AZA) and Foscarnet (phosphonoformate trisodium salt).
Active Site:
ACT_SITE 84 84 Proton acceptor.
Cross Reference Drug Bank:
DB00819 DB00909
Gene Ontology Go:
integral component of membrane
plasma membrane
carbonate dehydratase activity
metal ion binding
bicarbonate transport
small molecule metabolic process
Gene Ontology Biological Process:
bicarbonate transport
small molecule metabolic process
Gene Ontology Molecular Function:
carbonate dehydratase activity
metal ion binding
Gene Ontology Cellular Component:
integral component of membrane
plasma membrane
Keywords:
3D-structure
Complete proteome
Disulfide bond
Glycoprotein
Lyase
Membrane
Metal-binding
Phosphoprotein
Reference proteome
Signal
Transmembrane
Transmembrane helix
Zinc

Publication

PubMed ID:
10512682 12975309 14702039 16710414 15489334 16807956 16686544 17705204 17127057 17314045 19186056 19206230 18618712 21406692 24275569 24374484