Names & Taxonomy
- Uniprot ID:
- Q9ULC6
- Entry Name:
- PADI1_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein-arginine deiminase type-1 (EC 3.5.3.15) (Peptidylarginine deiminase I) (Protein-arginine deiminase type I)
- Gene Names:
- PADI1 PAD1 PDI1
- Gene Names Primary:
- PADI1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 663
- Sequence:
- MAPKRVVQLSLKMPTHAVCVVGVEAHVDIHSDVPKGANSFRVSGSSGVEVFMVYNRTRVKEPIGKARWPLDTDADMVVSVGTASKELKDFKVRVSYFGEQEDQALGRSVLYLTGVDISLEVDTGRTGKVKRSQGDKKTWRWGPEGYGAILLVNCDRDNHRSAEPDLTHSWLMSLADLQDMSPMLLSCNGPDKLFDSHKLVLNVPFSDSKRVRVFCARGGNSLSDYKQVLGPQCLSYEVERQPGEQEIKFYVEGLTFPDADFLGLVSLSVSLVDPGTLPEVTLFTDTVGFRMAPWIMTPNTQPPEELYVCRVMDTHGSNEKFLEDMSYLTLKANCKLTICPQVENRNDRWIQDEMEFGYIEAPHKSFPVVFDSPRNRGLKDFPYKRILGPDFGYVTREIPLPGPSSLDSFGNLDVSPPVTVGGTEYPLGRILIGSSFPKSGGRQMARAVRNFLKAQQVQAPVELYSDWLSVGHVDEFLTFVPTSDQKGFRLLLASPSACLKLFQEKKEEGYGEAAQFDGLKHQAKRSINEMLADRHLQRDNLHAQKCIDWNRNVLKRELGLAESDIVDIPQLFFLKNFYAEAFFPDMVNMVVLGKYLGIPKPYGPIINGRCCLEEKVQSLLEPLGLHCIFIDDYLSYHELQGEIHCGTNVRRKPFPFKWWNMVP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Catalyzes the deimination of arginine residues of proteins.
- Catalytic Activity:
- Protein L-arginine + H(2)O = protein L-citrulline + NH(3).
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Cross Reference Drug Bank:
- DB00155
- Gene Ontology Go:
- cytoplasm
extracellular exosome
calcium ion binding
protein-arginine deiminase activity
protein citrullination - Gene Ontology Biological Process:
- protein citrullination
- Gene Ontology Molecular Function:
- calcium ion binding
protein-arginine deiminase activity - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome - Keywords:
- Calcium
Complete proteome
Cytoplasm
Hydrolase
Polymorphism
Reference proteome