Names & Taxonomy

Uniprot ID:
Q9ULB1
Entry Name:
NRX1A_HUMAN
Status:
reviewed
Protein Names:
Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha)
Gene Names:
NRXN1 KIAA0578
Gene Names Primary:
NRXN1
Organism:
Homo sapiens (Human)

Structure

Length:
1477
Sequence:
MGTALLQRGGCFLLCLSLLLLGCWAELGSGLEFPGAEGQWTRFPKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGKSADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFNDNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQSTAGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIADPVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKIDTKITTQITAGARNLDLKSDLYIGGVAKETYKSLPKLVHAKEGFQGCLASVDLNGRLPDLISDALFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSSNKNKKNKDKEYYV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (By similarity).
Gene Ontology Go:
cell junction
cell surface
endoplasmic reticulum
integral component of plasma membrane
neuronal cell body
nuclear membrane
plasma membrane
presynapse
presynaptic membrane
protein complex
vesicle
acetylcholine receptor binding
calcium channel regulator activity
calcium ion binding
cell adhesion molecule binding
neuroligin family protein binding
receptor activity
adult behavior
axon guidance
extracellular matrix organization
gephyrin clustering involved in postsynaptic density assembly
learning
neuroligin clustering involved in postsynaptic membrane assembly
neuromuscular process controlling balance
neuron cell-cell adhesion
neurotransmitter secretion
positive regulation of excitatory postsynaptic potential
positive regulation of synapse assembly
positive regulation of synapse maturation
positive regulation of synaptic transmission, glutamatergic
postsynaptic density protein 95 clustering
postsynaptic membrane assembly
prepulse inhibition
regulation of grooming behavior
regulation of insulin secretion involved in cellular response to glucose stimulus
social behavior
synapse assembly
synaptic transmission
vocal learning
vocalization behavior
Gene Ontology Biological Process:
adult behavior
axon guidance
extracellular matrix organization
gephyrin clustering involved in postsynaptic density assembly
learning
neuroligin clustering involved in postsynaptic membrane assembly
neuromuscular process controlling balance
neuron cell-cell adhesion
neurotransmitter secretion
positive regulation of excitatory postsynaptic potential
positive regulation of synapse assembly
positive regulation of synapse maturation
positive regulation of synaptic transmission, glutamatergic
postsynaptic density protein 95 clustering
postsynaptic membrane assembly
prepulse inhibition
regulation of grooming behavior
regulation of insulin secretion involved in cellular response to glucose stimulus
social behavior
synapse assembly
synaptic transmission
vocalization behavior
vocal learning
Gene Ontology Molecular Function:
acetylcholine receptor binding
calcium channel regulator activity
calcium ion binding
cell adhesion molecule binding
neuroligin family protein binding
receptor activity
Gene Ontology Cellular Component:
cell junction
cell surface
endoplasmic reticulum
integral component of plasma membrane
neuronal cell body
nuclear membrane
plasma membrane
presynapse
presynaptic membrane
protein complex
vesicle
Keywords:
Alternative promoter usage
Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Complete proteome
Disulfide bond
EGF-like domain
Glycoprotein
Membrane
Metal-binding
Polymorphism
Reference proteome
Repeat
Signal
Synapse
Transmembrane
Transmembrane helix

Publication

PubMed ID:
18179900 9628581 12168954 11230166 15815621 11944992 22892527