Names & Taxonomy
- Uniprot ID:
- Q9UKV0
- Entry Name:
- HDAC9_HUMAN
- Status:
- reviewed
- Protein Names:
- Histone deacetylase 9 (HD9) (EC 3.5.1.98) (Histone deacetylase 7B) (HD7) (HD7b) (Histone deacetylase-related protein) (MEF2-interacting transcription repressor MITR)
- Gene Names:
- HDAC9 HDAC7 HDAC7B HDRP KIAA0744 MITR
- Gene Names Primary:
- HDAC9
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1011
- Sequence:
- MHSMISSVDVKSEVPVGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDAKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVTESSVSSSSPGSGPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSQLNASNSLKEKQKCETQTLRQGVPLPGQYGGSIPASSSHPHVTLEGKPPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQAMQEDRAPSSGNSTRSDSSACVDDTLGQVGAVKVKEEPVDSDEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSSPAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSMSLKFS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription.; Isoform 3 lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN transcription via HDAC1 recruitment to JUN promoter.
- Catalytic Activity:
- Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by Trichostatin A (TSA) and suberoylanilide hydroxamic acid.
- Active Site:
- ACT_SITE 783 783
- Cross Reference Drug Bank:
- DB06603 DB00313
- Gene Ontology Go:
- cytoplasm
histone deacetylase complex
histone methyltransferase complex
nucleoplasm
nucleus
transcription factor complex
histone deacetylase activity
histone deacetylase binding
metal ion binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein deacetylase activity
protein kinase C binding
repressing transcription factor binding
transcription corepressor activity
transcription factor binding
B cell activation
B cell differentiation
cellular response to insulin stimulus
heart development
histone deacetylation
histone H3 deacetylation
histone H4 deacetylation
inflammatory response
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
neuron differentiation
Notch signaling pathway
peptidyl-lysine deacetylation
positive regulation of cell migration involved in sprouting angiogenesis
regulation of skeletal muscle fiber development
regulation of striated muscle cell differentiation
response to amphetamine
transcription, DNA-templated - Gene Ontology Biological Process:
- B cell activation
B cell differentiation
cellular response to insulin stimulus
heart development
histone deacetylation
histone H3 deacetylation
histone H4 deacetylation
inflammatory response
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
neuron differentiation
Notch signaling pathway
peptidyl-lysine deacetylation
positive regulation of cell migration involved in sprouting angiogenesis
regulation of skeletal muscle fiber development
regulation of striated muscle cell differentiation
response to amphetamine
transcription, DNA-templated - Gene Ontology Molecular Function:
- histone deacetylase activity
histone deacetylase binding
metal ion binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein deacetylase activity
protein kinase C binding
repressing transcription factor binding
transcription corepressor activity
transcription factor binding - Gene Ontology Cellular Component:
- cytoplasm
histone deacetylase complex
histone methyltransferase complex
nucleoplasm
nucleus
transcription factor complex - Keywords:
- Alternative splicing
Chromatin regulator
Chromosomal rearrangement
Complete proteome
Hydrolase
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repressor
Transcription
Transcription regulation
Ubl conjugation
Zinc - Interacts With:
- P41182; P41212; Q60974