Names & Taxonomy
- Uniprot ID:
- Q9UK96
- Entry Name:
- FBX10_HUMAN
- Status:
- reviewed
- Protein Names:
- F-box only protein 10
- Gene Names:
- FBXO10 FBX10 PRMT11
- Gene Names Primary:
- FBXO10
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 956
- Sequence:
- MEAGGLPLELWRMILAYLHLPDLGRCSLVCRAWYELILSLDSTRWRQLCLGCTECRHPNWPNQPDVEPESWREAFKQHYLASKTWTKNALDLESSICFSLFRRRRERRTLSVGPGREFDSLGSALAMASLYDRIVLFPGVYEEQGEIILKVPVEIVGQGKLGEVALLASIDQHCSTTRLCNLVFTPAWFSPIMYKTTSGHVQFDNCNFENGHIQVHGPGTCQVKFCTFKNTHIFLHNVPLCVLENCEFVGSENNSVTVEGHPSADKNWAYKYLLGLIKSSPTFLPTEDSDFLMSLDLESRDQAWSPKTCDIVIEGSQSPTSPASSSPKPGSKAGSQEAEVGSDGERVAQTPDSSDGGLSPSGEDEDEDQLMYRLSYQVQGPRPVLGGSFLGPPLPGASIQLPSCLVLNSLQQELQKDKEAMALANSVQGCLIRKCLFRDGKGGVFVCSHGRAKMEGNIFRNLTYAVRCIHNSKIIMLRNDIYRCRASGIFLRLEGGGLIAGNNIYHNAEAGVDIRKKSNPLILCNQIHHGLRSGIVVLGNGKGIIRNNQIFSNKEAGIYILYHGNPVVSGNHIFKGRAAGIAVNENGKGLITENVIRENQWGGVDIRRGGIPVLRSNLICFGYSDGVVVGDEGKGLIEGNTIYANKGCGVWMMSSSLPHVTSNHVSYNGLYGVAVFSQKDGSSELPRGHRAQENFSEDGDAILWETELEKEDDPLRRPITIALVESNSINHNGASGLYVQSSEALHVITNVIHANGDRGITVAQSSQPTRVANNSISCNRQSGVKVEAQCKVELRGNGIYDNRGHGIITKGDSTIVIENDIIGNRGSGLQLLPRSDTKVIKNRIHSFRAYGIAVRGRAKALVQENIIFQGKTSKTIFQQISNNRECIMQNNKFLVFKKKSDTWRLVNPPARPHLENSLRRPSAAHNGQKVTAMATRITARVEGGYHSNRSVFCTIL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2.
- Pathway:
- Protein modification; protein ubiquitination.
- Gene Ontology Go:
- cytoplasm
ubiquitin ligase complex
ubiquitin-protein transferase activity
apoptotic process
protein ubiquitination
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of apoptotic process - Gene Ontology Biological Process:
- apoptotic process
protein ubiquitination
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of apoptotic process - Gene Ontology Molecular Function:
- ubiquitin-protein transferase activity
- Gene Ontology Cellular Component:
- cytoplasm
ubiquitin ligase complex - Keywords:
- Alternative splicing
Apoptosis
Complete proteome
Cytoplasm
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Ubl conjugation pathway