Names & Taxonomy
- Uniprot ID:
- Q9UJ68
- Entry Name:
- MSRA_HUMAN
- Status:
- reviewed
- Protein Names:
- Mitochondrial peptide methionine sulfoxide reductase (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) (Protein-methionine-S-oxide reductase) (PMSR)
- Gene Names:
- MSRA
- Gene Names Primary:
- MSRA
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 235
- Sequence:
- MLSATRRACQLLLLHSLFPVPRMGNSASNIVSPQEALPGRKEQTPVAAKHHVNGNRTVEPFPEGTQMAVFGMGCFWGAERKFWVLKGVYSTQVGFAGGYTSNPTYKEVCSEKTGHAEVVRVVYQPEHMSFEELLKVFWENHDPTQGMRQGNDHGTQYRSAIYPTSAKQMEAALSSKENYQKVLSEHGFGPITTDIREGQTFYYAEDYHQQYLSKNPNGYCGLGGTGVSCPVGIKK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Mitochondrion.; Isoform 2: Cytoplasm.; Isoform 3: Cytoplasm. Nucleus.; Isoform 5: Cytoplasm. Membrane
Function
- Function:
- Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
- Catalytic Activity:
- Peptide-L-methionine + thioredoxin disulfide + H(2)O = peptide-L-methionine (S)-S-oxide + thioredoxin.; L-methionine + thioredoxin disulfide + H(2)O = L-methionine (S)-S-oxide + thioredoxin.
- Cross Reference Drug Bank:
- DB00134
- Gene Ontology Go:
- actin cytoskeleton
cytoplasm
cytosol
extracellular exosome
membrane
mitochondrion
nucleoplasm
peptide-methionine (S)-S-oxide reductase activity
cellular protein metabolic process
cellular protein modification process
methionine metabolic process
protein repair
response to oxidative stress - Gene Ontology Biological Process:
- cellular protein metabolic process
cellular protein modification process
methionine metabolic process
protein repair
response to oxidative stress - Gene Ontology Molecular Function:
- peptide-methionine (S)-S-oxide reductase activity
- Gene Ontology Cellular Component:
- actin cytoskeleton
cytoplasm
cytosol
extracellular exosome
membrane
mitochondrion
nucleoplasm - Keywords:
- Acetylation
Alternative initiation
Alternative promoter usage
Alternative splicing
Complete proteome
Cytoplasm
Lipoprotein
Membrane
Mitochondrion
Myristate
Nucleus
Oxidoreductase
Reference proteome
Transit peptide