Names & Taxonomy
- Uniprot ID:
- Q9UI32
- Entry Name:
- GLSL_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutaminase liver isoform, mitochondrial (GLS) (EC 3.5.1.2) (L-glutaminase) (L-glutamine amidohydrolase)
- Gene Names:
- GLS2 GA
- Gene Names Primary:
- GLS2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 602
- Sequence:
- MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQDHDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVAAYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHKFVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAGNEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESGSVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGAEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLESMV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion
Function
- Function:
- Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.
- Catalytic Activity:
- L-glutamine + H(2)O = L-glutamate + NH(3).
- Cross Reference Drug Bank:
- DB00130
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
presynapse
glutaminase activity
cellular amino acid biosynthetic process
cellular amino acid metabolic process
cellular nitrogen compound metabolic process
gene expression
glutamate biosynthetic process
glutamate secretion
glutamine catabolic process
neurotransmitter secretion
positive regulation of protein targeting to mitochondrion
reactive oxygen species metabolic process
regulation of apoptotic process
small molecule metabolic process
synaptic transmission
transcription initiation from RNA polymerase II promoter - Gene Ontology Biological Process:
- cellular amino acid biosynthetic process
cellular amino acid metabolic process
cellular nitrogen compound metabolic process
gene expression
glutamate biosynthetic process
glutamate secretion
glutamine catabolic process
neurotransmitter secretion
positive regulation of protein targeting to mitochondrion
reactive oxygen species metabolic process
regulation of apoptotic process
small molecule metabolic process
synaptic transmission
transcription initiation from RNA polymerase II promoter - Gene Ontology Molecular Function:
- glutaminase activity
- Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion
presynapse - Keywords:
- 3D-structure
ANK repeat
Acetylation
Alternative splicing
Complete proteome
Hydrolase
Mitochondrion
Polymorphism
Reference proteome
Repeat
Transit peptide