Names & Taxonomy

Uniprot ID:
Q9UI32
Entry Name:
GLSL_HUMAN
Status:
reviewed
Protein Names:
Glutaminase liver isoform, mitochondrial (GLS) (EC 3.5.1.2) (L-glutaminase) (L-glutamine amidohydrolase)
Gene Names:
GLS2 GA
Gene Names Primary:
GLS2
Organism:
Homo sapiens (Human)

Structure

Length:
602
Sequence:
MRSMKALQKALSRAGSHCGRGGWGHPSRSPLLGGGVRHHLSEAAAQGRETPHSHQPQHQDHDSSESGMLSRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLRDCMSEMHRVVQESSSGGLLDRDLFRKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDVKELTGGKVAAYIPQLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISISTLGTDYVHKFVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAGNEYMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESGSVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLVVPNVMGMMCLSPPLDKLGNSHRGTSFCQKLVSLFNFHNYDNLRHCARKLDPRREGAEIRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFAKDRWGNIPLDDAVQFNHLEVVKLLQDYQDSYTLSETQAEAAAEALSKENLESMV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion

Function

Function:
Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.
Catalytic Activity:
L-glutamine + H(2)O = L-glutamate + NH(3).
Cross Reference Drug Bank:
DB00130
Gene Ontology Go:
mitochondrial matrix
mitochondrion
presynapse
glutaminase activity
cellular amino acid biosynthetic process
cellular amino acid metabolic process
cellular nitrogen compound metabolic process
gene expression
glutamate biosynthetic process
glutamate secretion
glutamine catabolic process
neurotransmitter secretion
positive regulation of protein targeting to mitochondrion
reactive oxygen species metabolic process
regulation of apoptotic process
small molecule metabolic process
synaptic transmission
transcription initiation from RNA polymerase II promoter
Gene Ontology Biological Process:
cellular amino acid biosynthetic process
cellular amino acid metabolic process
cellular nitrogen compound metabolic process
gene expression
glutamate biosynthetic process
glutamate secretion
glutamine catabolic process
neurotransmitter secretion
positive regulation of protein targeting to mitochondrion
reactive oxygen species metabolic process
regulation of apoptotic process
small molecule metabolic process
synaptic transmission
transcription initiation from RNA polymerase II promoter
Gene Ontology Molecular Function:
glutaminase activity
Gene Ontology Cellular Component:
mitochondrial matrix
mitochondrion
presynapse
Keywords:
3D-structure
ANK repeat
Acetylation
Alternative splicing
Complete proteome
Hydrolase
Mitochondrion
Polymorphism
Reference proteome
Repeat
Transit peptide

Publication

PubMed ID:
10620514 12444921 14702039 16541075 11163757 20378837 24275569