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Uniprot ID:: Q9UHQ9
Entry Name:: NB5R1_HUMAN
Status:: reviewed
Protein Names:: NADH-cytochrome b5 reductase 1 (b5R.1) (EC 1.6.2.2) (Humb5R2) (NAD(P)H:quinone oxidoreductase type 3 polypeptide A2)
Gene Names:: CYB5R1 NQO3A2 UNQ3049/PRO9865
Gene Names Orf:: UNQ3049/PRO9865
Gene Names Primary:: CYB5R1
Organism:: Homo sapiens (Human)

Length:: 305
Sequence:: MGIQTSPVLLASLGVGLVTLLGLAVGSYLVRRSRRPQVTLLDPNEKYLLRLLDKTTVSHNTKRFRFALPTAHHTLGLPVGKHIYLSTRIDGSLVIRPYTPVTSDEDQGYVDLVIKVYLKGVHPKFPEGGKMSQYLDSLKVGDVVEFRGPSGLLTYTGKGHFNIQPNKKSPPEPRVAKKLGMIAGGTGITPMLQLIRAILKVPEDPTQCFLLFANQTEKDIILREDLEELQARYPNRFKLWFTLDHPPKDWAYSKGFVTADMIREHLPAPGDDVLVLLCGPPPMVQLACHPNLDKLGYSQKMRFTY
Proteomes:: UP000005640

Function:: NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
Catalytic Activity:: NADH + 2 ferricytochrome b5 = NAD(+) + H(+) + 2 ferrocytochrome b5.
Cofactor:: COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
Cross Reference Drug Bank:: DB03147
Gene Ontology Go:: extracellular exosome
integral component of membrane
membrane
mitochondrion
cytochrome-b5 reductase activity, acting on NAD(P)H
positive regulation of protein targeting to mitochondrion
sterol biosynthetic process
Gene Ontology Biological Process:: positive regulation of protein targeting to mitochondrion
sterol biosynthetic process
Gene Ontology Molecular Function:: cytochrome-b5 reductase activity, acting on NAD(P)H
Gene Ontology Cellular Component:: extracellular exosome
integral component of membrane
membrane
mitochondrion
Keywords:: Complete proteome
Direct protein sequencing
FAD
Flavoprotein
Lipid biosynthesis
Lipid metabolism
Membrane
NAD
Oxidoreductase
Polymorphism
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol biosynthesis
Sterol metabolism
Transmembrane
Transmembrane helix
Interacts With:: Q9UMX0; Q9UMX0-2