Names & Taxonomy
- Uniprot ID:
- A4ZMU3
- Entry Name:
- A4ZMU3_HUMAN
- Status:
- unreviewed
- Protein Names:
- NADH-ubiquinone oxidoreductase chain 5 (EC 1.6.5.3)
- Gene Names:
- ND5
- Gene Names Primary:
- ND5
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 603
- Sequence:
- MTMYTTMTTLTLTSLIPPILTTFVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLTANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane
- Gene Encoded:
- Mitochondrion
Function
- Function:
- Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
- Catalytic Activity:
- NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).
- Gene Ontology Go:
- integral component of membrane
mitochondrial inner membrane
respiratory chain
NADH dehydrogenase (ubiquinone) activity
ATP synthesis coupled electron transport - Gene Ontology Biological Process:
- ATP synthesis coupled electron transport
- Gene Ontology Molecular Function:
- NADH dehydrogenase (ubiquinone) activity
- Gene Ontology Cellular Component:
- integral component of membrane
mitochondrial inner membrane
respiratory chain - Keywords:
- Electron transport
Membrane
Mitochondrion
Mitochondrion inner membrane
NAD
Oxidoreductase
Respiratory chain
Transmembrane
Transmembrane helix
Transport
Ubiquinone
Publication
- PubMed ID:
- 17194802