Names & Taxonomy

Uniprot ID:
A4ZMU3
Entry Name:
A4ZMU3_HUMAN
Status:
unreviewed
Protein Names:
NADH-ubiquinone oxidoreductase chain 5 (EC 1.6.5.3)
Gene Names:
ND5
Gene Names Primary:
ND5
Organism:
Homo sapiens (Human)

Structure

Length:
603
Sequence:
MTMYTTMTTLTLTSLIPPILTTFVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLTANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLLLIT

Subcellular location

Subcellular Location:
Mitochondrion inner membrane
Gene Encoded:
Mitochondrion

Function

Function:
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Catalytic Activity:
NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out).
Gene Ontology Go:
integral component of membrane
mitochondrial inner membrane
respiratory chain
NADH dehydrogenase (ubiquinone) activity
ATP synthesis coupled electron transport
Gene Ontology Biological Process:
ATP synthesis coupled electron transport
Gene Ontology Molecular Function:
NADH dehydrogenase (ubiquinone) activity
Gene Ontology Cellular Component:
integral component of membrane
mitochondrial inner membrane
respiratory chain
Keywords:
Electron transport
Membrane
Mitochondrion
Mitochondrion inner membrane
NAD
Oxidoreductase
Respiratory chain
Transmembrane
Transmembrane helix
Transport
Ubiquinone

Publication

PubMed ID:
17194802