Names & Taxonomy
- Uniprot ID:
- Q9UG56
- Entry Name:
- PISD_HUMAN
- Status:
- reviewed
- Protein Names:
- Phosphatidylserine decarboxylase proenzyme, mitochondrial (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase beta chain; Phosphatidylserine decarboxylase alpha chain]
- Gene Names:
- PISD
- Gene Names Primary:
- PISD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 409
- Sequence:
- MATSVGHRCLGLLHGVAPWRSSLHPCEITALSQSLQPLRKLPFRAFRTDARKIHTAPARTMFLLRPLPILLVTGGGYAGYRQYEKYRERELEKLGLEIPPKLAGHWEVALYKSVPTRLLSRAWGRLNQVELPHWLRRPVYSLYIWTFGVNMKEAAVEDLHHYRNLSEFFRRKLKPQARPVCGLHSVISPSDGRILNFGQVKNCEVEQVKGVTYSLESFLGPRMCTEDLPFPPAASCDSFKNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIYFDRDLHTNSPRHSKGSYNDFSFVTHTNREGVPMRKGEHLGEFNLGSTIVLIFEAPKDFNFQLKTGQKIRFGEALGSL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Phosphatidylserine decarboxylase beta chain: Mitochondrion inner membrane
Function
- Function:
- Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
- Catalytic Activity:
- Phosphatidyl-L-serine = phosphatidylethanolamine + CO(2).
- Cofactor:
- COFACTOR: Name=pyruvate; Xref=ChEBI:CHEBI:15361;
- Active Site:
- ACT_SITE 191 191 Charge relay system; for autoendoproteolytic cleavage activity.
- Cross Reference Drug Bank:
- DB00144
- Gene Ontology Go:
- integral component of membrane
mitochondrial inner membrane
nucleus
phosphatidylserine decarboxylase activity
glycerophospholipid biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- glycerophospholipid biosynthetic process
phosphatidylethanolamine biosynthetic process
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- phosphatidylserine decarboxylase activity
- Gene Ontology Cellular Component:
- integral component of membrane
mitochondrial inner membrane
nucleus - Keywords:
- Alternative splicing
Complete proteome
Decarboxylase
Lipid biosynthesis
Lipid metabolism
Lyase
Membrane
Mitochondrion
Mitochondrion inner membrane
Phospholipid biosynthesis
Phospholipid metabolism
Pyruvate
Reference proteome
Transit peptide
Transmembrane
Transmembrane helix
Zymogen