Names & Taxonomy
- Uniprot ID:
- Q9UBY5
- Entry Name:
- LPAR3_HUMAN
- Status:
- reviewed
- Protein Names:
- Lysophosphatidic acid receptor 3 (LPA receptor 3) (LPA-3) (Lysophosphatidic acid receptor Edg-7)
- Gene Names:
- LPAR3 EDG7 LPA3
- Gene Names Primary:
- LPAR3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 353
- Sequence:
- MNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFAGIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein.
Function
- Function:
- Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.
- Gene Ontology Go:
- axon
cytosol
integral component of plasma membrane
plasma membrane
G-protein coupled receptor activity
lipid binding
lysophosphatidic acid receptor activity
phospholipid binding
activation of MAPK activity
bleb assembly
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of calcium ion transport
positive regulation of collateral sprouting
positive regulation of cytosolic calcium ion concentration
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
synaptic transmission - Gene Ontology Biological Process:
- activation of MAPK activity
bleb assembly
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of calcium ion transport
positive regulation of collateral sprouting
positive regulation of cytosolic calcium ion concentration
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
synaptic transmission - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
lipid binding
lysophosphatidic acid receptor activity
phospholipid binding - Gene Ontology Cellular Component:
- axon
cytosol
integral component of plasma membrane
plasma membrane - Keywords:
- Cell membrane
Complete proteome
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Polymorphism
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix