Names & Taxonomy
- Uniprot ID:
- Q9UBR2
- Entry Name:
- CATZ_HUMAN
- Status:
- reviewed
- Protein Names:
- Cathepsin Z (EC 3.4.18.1) (Cathepsin P) (Cathepsin X)
- Gene Names:
- CTSZ
- Gene Names Primary:
- CTSZ
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 303
- Sequence:
- MARRGPGWRPLLLLVLLAGAAQGGLYFRRGQTCYRPLRGDGLAPLGRSTYPRPHEYLSPADLPKSWDWRNVDGVNYASITRNQHIPQYCGSCWAHASTSAMADRINIKRKGAWPSTLLSVQNVIDCGNAGSCEGGNDLSVWDYAHQHGIPDETCNNYQAKDQECDKFNQCGTCNEFKECHAIRNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATERLANYTGGIYAEYQDTTYINHVVSVAGWGISDGTEYWIVRNSWGEPWGERGWLRIVTSTYKDGKGARYNLAIEEHCTFGDPIV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome.
Function
- Function:
- Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity.
- Catalytic Activity:
- Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.
- Active Site:
- ACT_SITE 92 92; ACT_SITE 241 241; ACT_SITE 261 261
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum lumen
endoplasmic reticulum-Golgi intermediate compartment membrane
ER to Golgi transport vesicle
extracellular exosome
extracellular space
Golgi membrane
intracellular membrane-bounded organelle
lysosome
plasma membrane
cysteine-type endopeptidase activity
cysteine-type peptidase activity
angiotensin maturation
cellular protein metabolic process
COPII vesicle coating
epithelial tube branching involved in lung morphogenesis
ER to Golgi vesicle-mediated transport
membrane organization
post-translational protein modification
protein N-linked glycosylation via asparagine
proteolysis
proteolysis involved in cellular protein catabolic process - Gene Ontology Biological Process:
- angiotensin maturation
cellular protein metabolic process
COPII vesicle coating
epithelial tube branching involved in lung morphogenesis
ER to Golgi vesicle-mediated transport
membrane organization
post-translational protein modification
protein N-linked glycosylation via asparagine
proteolysis
proteolysis involved in cellular protein catabolic process - Gene Ontology Molecular Function:
- cysteine-type endopeptidase activity
cysteine-type peptidase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum-Golgi intermediate compartment membrane
endoplasmic reticulum lumen
ER to Golgi transport vesicle
extracellular exosome
extracellular space
Golgi membrane
intracellular membrane-bounded organelle
lysosome
plasma membrane - Keywords:
- 3D-structure
Complete proteome
Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Polymorphism
Protease
Reference proteome
Signal
Thiol protease
Zymogen - Interacts With:
- Q6A162; P26371; Q9UJV3-2; Q5JR59; Q7Z3S9; O15162