Names & Taxonomy
- Uniprot ID:
- Q9UBM7
- Entry Name:
- DHCR7_HUMAN
- Status:
- reviewed
- Protein Names:
- 7-dehydrocholesterol reductase (7-DHC reductase) (EC 1.3.1.21) (Putative sterol reductase SR-2) (Sterol Delta(7)-reductase)
- Gene Names:
- DHCR7 D7SR
- Gene Names Primary:
- DHCR7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 475
- Sequence:
- MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMACDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHKFLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDLFRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCLACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC).
- Pathway:
- Steroid biosynthesis; cholesterol biosynthesis.
- Catalytic Activity:
- Cholesterol + NADP(+) = cholesta-5,7-dien-3-beta-ol + NADPH.
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of endoplasmic reticulum membrane
membrane
nuclear outer membrane
7-dehydrocholesterol reductase activity
blood vessel development
cell differentiation
cholesterol biosynthetic process
cholesterol biosynthetic process via desmosterol
cholesterol biosynthetic process via lathosterol
lung development
multicellular organism growth
post-embryonic development
regulation of cell proliferation
regulation of cholesterol biosynthetic process
small molecule metabolic process - Gene Ontology Biological Process:
- blood vessel development
cell differentiation
cholesterol biosynthetic process
cholesterol biosynthetic process via desmosterol
cholesterol biosynthetic process via lathosterol
lung development
multicellular organism growth
post-embryonic development
regulation of cell proliferation
regulation of cholesterol biosynthetic process
small molecule metabolic process - Gene Ontology Molecular Function:
- 7-dehydrocholesterol reductase activity
- Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of endoplasmic reticulum membrane
membrane
nuclear outer membrane - Keywords:
- Cholesterol biosynthesis
Cholesterol metabolism
Complete proteome
Disease mutation
Endoplasmic reticulum
Lipid biosynthesis
Lipid metabolism
Membrane
NADP
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol biosynthesis
Sterol metabolism
Transmembrane
Transmembrane helix