Names & Taxonomy
- Uniprot ID:
- Q9UBK8
- Entry Name:
- MTRR_HUMAN
- Status:
- reviewed
- Protein Names:
- Methionine synthase reductase (MSR) (EC 1.16.1.8)
- Gene Names:
- MTRR
- Gene Names Primary:
- MTRR
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 725
- Sequence:
- MGAASVRAGARLVEVALCSFTVTCLEVMRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAPLVVVVSTTGTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLEDKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPLSLLLEHLPKLQPRPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQDIWS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform B: Cytoplasm.; Isoform C: Cytoplasm.; Isoform A: Cytoplasm
Function
- Function:
- Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary for utilization of methylgroups from the folate cycle, thereby affecting transgenerational epigenetic inheritance. Folate pathway donates methyl groups necessary for cellular methylation and affects different pathways such as DNA methylation, possibly explaining the transgenerational epigenetic inheritance effects.
- Catalytic Activity:
- 2 -methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP(+) = 2 -cob(II)alamin + NADPH + 2 S-adenosyl-L-methionine.
- Cofactor:
- COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=2.89 uM for NADPH
- Cross Reference Drug Bank:
- DB00115 DB00200 DB00134
- Gene Ontology Go:
- cytoplasm
cytosol
intermediate filament cytoskeleton
nucleoplasm
reductase activity
aquacobalamin reductase (NADPH) activity
FAD binding
flavin adenine dinucleotide binding
FMN binding
iron ion binding
NADP binding
NADPH binding
NADPH-hemoprotein reductase activity
oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
cellular nitrogen compound metabolic process
cobalamin metabolic process
DNA methylation
folic acid metabolic process
homocysteine catabolic process
methionine biosynthetic process
methionine metabolic process
methylation
negative regulation of cystathionine beta-synthase activity
oxidation-reduction process
S-adenosylmethionine cycle
small molecule metabolic process
sulfur amino acid metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular nitrogen compound metabolic process
cobalamin metabolic process
DNA methylation
folic acid metabolic process
homocysteine catabolic process
methionine biosynthetic process
methionine metabolic process
methylation
negative regulation of cystathionine beta-synthase activity
oxidation-reduction process
S-adenosylmethionine cycle
small molecule metabolic process
sulfur amino acid metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- reductase activity
aquacobalamin reductase (NADPH) activity
FAD binding
flavin adenine dinucleotide binding
FMN binding
iron ion binding
NADP binding
NADPH binding
NADPH-hemoprotein reductase activity
oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor - Gene Ontology Cellular Component:
- cytoplasm
cytosol
intermediate filament cytoskeleton
nucleoplasm - Keywords:
- 3D-structure
Alternative splicing
Amino-acid biosynthesis
Complete proteome
Cytoplasm
Disease mutation
FAD
FMN
Flavoprotein
Methionine biosynthesis
NADP
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
S-adenosyl-L-methionine - Interacts With:
- Q53SE7