Names & Taxonomy
- Uniprot ID:
- Q9P2K5
- Entry Name:
- MYEF2_HUMAN
- Status:
- reviewed
- Protein Names:
- Myelin expression factor 2 (MEF-2) (MyEF-2) (MST156)
- Gene Names:
- MYEF2 KIAA1341
- Gene Names Primary:
- MYEF2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 600
- Sequence:
- MADANKAEVPGATGGDSPHLQPAEPPGEPRREPHPAEAEKQQPQHSSSSNGVKMENDESAKEEKSDLKEKSTGSKKANRFHPYSKDKNSGAGEKKGPNRNRVFISNIPYDMKWQAIKDLMREKVGEVTYVELFKDAEGKSRGCGVVEFKDEEFVKKALETMNKYDLSGRPLNIKEDPDGENARRALQRTGGSFPGGHVPDMGSGLMNLPPSILNNPNIPPEVISNLQAGRLGSTIFVANLDFKVGWKKLKEVFSIAGTVKRADIKEDKDGKSRGMGTVTFEQAIEAVQAISMFNGQFLFDRPMHVKMDDKSVPHEEYRSHDGKTPQLPRGLGGIGMGLGPGGQPISASQLNIGGVMGNLGPGGMGMDGPGFGGMNRIGGGIGFGGLEAMNSMGGFGGVGRMGELYRGAMTSSMERDFGRGDIGINQGFGDSFGRLGSAMIGGFAGRIGSSNMGPVGSGISGGMGSMNSVTGGMGMGLDRMSSSFDRMGPGIGAILERSIDMDRGFLSGPMGSGMRERIGSKGNQIFVRNLPFDLTWQKLKEKFSQCGHVMFAEIKMENGKSKGCGTVRFDSPESAEKACRIMNGIKISGREIDVRLDRNA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus.
Function
- Function:
- Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity).
- Gene Ontology Go:
- cytoplasm
nucleoplasm
nucleus
DNA binding
nucleotide binding
poly(A) RNA binding
myotube differentiation
neuron differentiation
transcription, DNA-templated - Gene Ontology Biological Process:
- myotube differentiation
neuron differentiation
transcription, DNA-templated - Gene Ontology Molecular Function:
- DNA binding
nucleotide binding
poly(A) RNA binding - Gene Ontology Cellular Component:
- cytoplasm
nucleoplasm
nucleus - Keywords:
- Alternative splicing
Complete proteome
DNA-binding
Nucleus
Phosphoprotein
Polymorphism
RNA-binding
Reference proteome
Repeat
Repressor
Transcription - Interacts With:
- Q96MW5; Q08379; Q8IYF3; Q13077