Names & Taxonomy
- Uniprot ID:
- Q9P0L9
- Entry Name:
- PK2L1_HUMAN
- Status:
- reviewed
- Protein Names:
- Polycystic kidney disease 2-like 1 protein (Polycystin-2 homolog) (Polycystin-2L1) (Polycystin-L) (Polycystin-L1)
- Gene Names:
- PKD2L1 PKD2L PKDL TRPP3
- Gene Names Primary:
- PKD2L1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 805
- Sequence:
- MNAVGSPEGQELQKLGSGAWDNPAYSGPPSPHGTLRVCTISSTGPLQPQPKKPEDEPQETAYRTQVSSCCLHICQGIRGLWGTTLTENTAENRELYIKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDTGVSFQAISSMADFWDFAQGPLLDSLYWTKWYNNQSLGHGSHSFIYYENMLLGVPRLRQLKVRNDSCVVHEDFREDILSCYDVYSPDKEEQLPFGPFNGTAWTYHSQDELGGFSHWGRLTSYSGGGYYLDLPGSRQGSAEALRALQEGLWLDRGTRVVFIDFSVYNANINLFCVLRLVVEFPATGGAIPSWQIRTVKLIRYVSNWDFFIVGCEVIFCVFIFYYVVEEILELHIHRLRYLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPNTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQVENFSTFIKCIFTQFRIILGDFDYNAIDNANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDELQLSDLLKQGYNKTLLRLRLRKERVSDVQKVLQGGEQEIQFEDFTNTLRELGHAEHEITELTATFTKFDRDGNRILDEKEQEKMRQDLEEERVALNTEIEKLGRSIVSSPQGKSGPEAARAGGWVSGEEFYMLTRRVLQLETVLEGVVSQIDAVGSKLKMLERKGWLAPSPGVKEQAIWKHPQPAPAVTPDPWGVQGGQESEVPYKREEEALEERRLSRGEIPTLQRS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum
Function
- Function:
- Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.
- Enzyme Regulation:
- ENZYME REGULATION: The calcium channel is gated following an off-response property by acid: gated open after the removal of acid stimulus, but not during acid application.
- Gene Ontology Go:
- calcium channel complex
cell surface
ciliary membrane
endoplasmic reticulum
integral component of membrane
intracellular membrane-bounded organelle
membrane
nonmotile primary cilium
plasma membrane
receptor complex
alpha-actinin binding
calcium activated cation channel activity
calcium channel activity
calcium ion binding
calcium-activated potassium channel activity
cation channel activity
cytoskeletal protein binding
identical protein binding
muscle alpha-actinin binding
sodium channel activity
sour taste receptor activity
cation transport
cellular response to acidic pH
detection of chemical stimulus involved in sensory perception of sour taste
detection of mechanical stimulus
potassium ion transmembrane transport
protein homotrimerization
sensory perception of sour taste
smoothened signaling pathway
sodium ion transmembrane transport - Gene Ontology Biological Process:
- cation transport
cellular response to acidic pH
detection of chemical stimulus involved in sensory perception of sour taste
detection of mechanical stimulus
potassium ion transmembrane transport
protein homotrimerization
sensory perception of sour taste
smoothened signaling pathway
sodium ion transmembrane transport - Gene Ontology Molecular Function:
- alpha-actinin binding
calcium activated cation channel activity
calcium-activated potassium channel activity
calcium channel activity
calcium ion binding
cation channel activity
cytoskeletal protein binding
identical protein binding
muscle alpha-actinin binding
sodium channel activity
sour taste receptor activity - Gene Ontology Cellular Component:
- calcium channel complex
cell surface
ciliary membrane
endoplasmic reticulum
integral component of membrane
intracellular membrane-bounded organelle
membrane
nonmotile primary cilium
plasma membrane
receptor complex - Keywords:
- 3D-structure
Alternative splicing
Calcium
Calcium channel
Calcium transport
Cell membrane
Cell projection
Cilium
Coiled coil
Complete proteome
Endoplasmic reticulum
Glycoprotein
Ion channel
Ion transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport