Names & Taxonomy
- Uniprot ID:
- Q9NZV6
- Entry Name:
- MSRB1_HUMAN
- Status:
- reviewed
- Protein Names:
- Methionine-R-sulfoxide reductase B1 (MsrB1) (EC 1.8.4.-) (Selenoprotein X) (SelX)
- Gene Names:
- MSRB1 SEPX1 HSPC270
- Gene Names Orf:
- HSPC270
- Gene Names Primary:
- MSRB1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 116
- Sequence:
- MSFCSFFGGEVFQNHFEPGVYVCAKCGYELFSSRSKYAHSSPWPAFTETIHADSVAKRPEHNRSEALKVSCGKCGNGLGHEFLNDGPKPGQSRFUIFSSSLKFVPKGKETSASQGH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages (By similarity).
- Catalytic Activity:
- L-methionine + oxidized thioredoxin = L-methionine R-oxide + reduced thioredoxin.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Active Site:
- ACT_SITE 95 95 Nucleophile.
- Cross Reference Drug Bank:
- DB00134
- Gene Ontology Go:
- actin cytoskeleton
cytosol
nucleus
actin binding
methionine-R-sulfoxide reductase activity
peptide-methionine (R)-S-oxide reductase activity
zinc ion binding
actin filament polymerization
cellular protein metabolic process
innate immune response
protein repair
response to oxidative stress - Gene Ontology Biological Process:
- actin filament polymerization
cellular protein metabolic process
innate immune response
protein repair
response to oxidative stress - Gene Ontology Molecular Function:
- actin binding
methionine-R-sulfoxide reductase activity
peptide-methionine (R)-S-oxide reductase activity
zinc ion binding - Gene Ontology Cellular Component:
- actin cytoskeleton
cytosol
nucleus - Keywords:
- 3D-structure
Complete proteome
Cytoplasm
Cytoskeleton
Immunity
Innate immunity
Metal-binding
Nucleus
Oxidoreductase
Reference proteome
Selenocysteine
Zinc