Names & Taxonomy
- Uniprot ID:
- Q9NZK7
- Entry Name:
- PA2GE_HUMAN
- Status:
- reviewed
- Protein Names:
- Group IIE secretory phospholipase A2 (GIIE sPLA2) (sPLA2-IIE) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 2E)
- Gene Names:
- PLA2G2E
- Gene Names Primary:
- PLA2G2E
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 142
- Sequence:
- MKSPHVLVFLCLLVALVTGNLVQFGVMIEKMTGKSALQYNDYGCYCGIGGSHWPVDQTDWCCHAHDCCYGRLEKLGCEPKLEKYLFSVSERGIFCAGRTTCQRLTCECDKRAALCFRRNLGTYNRKYAHYPNKLCTGPTPPC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted.
Function
- Function:
- PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.
- Catalytic Activity:
- Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 1 Ca(2+) ion per subunit.;
- Active Site:
- ACT_SITE 65 65
- Cross Reference Drug Bank:
- DB00233 DB04743
- Gene Ontology Go:
- extracellular region
calcium ion binding
phospholipase A2 activity
glycerophospholipid biosynthetic process
inflammatory response
lipid catabolic process
phosphatidic acid biosynthetic process
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
phosphatidylglycerol acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- glycerophospholipid biosynthetic process
inflammatory response
lipid catabolic process
phosphatidic acid biosynthetic process
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
phosphatidylglycerol acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
phospholipid metabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- calcium ion binding
phospholipase A2 activity - Gene Ontology Cellular Component:
- extracellular region
- Keywords:
- Calcium
Complete proteome
Disulfide bond
Hydrolase
Lipid degradation
Lipid metabolism
Metal-binding
Reference proteome
Secreted
Signal