Names & Taxonomy

Uniprot ID:
Q9NZK7
Entry Name:
PA2GE_HUMAN
Status:
reviewed
Protein Names:
Group IIE secretory phospholipase A2 (GIIE sPLA2) (sPLA2-IIE) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 2E)
Gene Names:
PLA2G2E
Gene Names Primary:
PLA2G2E
Organism:
Homo sapiens (Human)

Structure

Length:
142
Sequence:
MKSPHVLVFLCLLVALVTGNLVQFGVMIEKMTGKSALQYNDYGCYCGIGGSHWPVDQTDWCCHAHDCCYGRLEKLGCEPKLEKYLFSVSERGIFCAGRTTCQRLTCECDKRAALCFRRNLGTYNRKYAHYPNKLCTGPTPPC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted.

Function

Function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.
Catalytic Activity:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; ; Note=Binds 1 Ca(2+) ion per subunit.;
Active Site:
ACT_SITE 65 65
Cross Reference Drug Bank:
DB00233 DB04743
Gene Ontology Go:
extracellular region
calcium ion binding
phospholipase A2 activity
glycerophospholipid biosynthetic process
inflammatory response
lipid catabolic process
phosphatidic acid biosynthetic process
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
phosphatidylglycerol acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
phospholipid metabolic process
small molecule metabolic process
Gene Ontology Biological Process:
glycerophospholipid biosynthetic process
inflammatory response
lipid catabolic process
phosphatidic acid biosynthetic process
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
phosphatidylglycerol acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
phospholipid metabolic process
small molecule metabolic process
Gene Ontology Molecular Function:
calcium ion binding
phospholipase A2 activity
Gene Ontology Cellular Component:
extracellular region
Keywords:
Calcium
Complete proteome
Disulfide bond
Hydrolase
Lipid degradation
Lipid metabolism
Metal-binding
Reference proteome
Secreted
Signal

Publication

PubMed ID:
10681567 16710414