Names & Taxonomy

Uniprot ID:
Q9NYR8
Entry Name:
RDH8_HUMAN
Status:
reviewed
Protein Names:
Retinol dehydrogenase 8 (EC 1.1.1.300) (Photoreceptor outer segment all-trans retinol dehydrogenase) (Short chain dehydrogenase/reductase family 28C member 2)
Gene Names:
RDH8 PRRDH SDR28C2
Gene Names Primary:
RDH8
Organism:
Homo sapiens (Human)

Structure

Length:
311
Sequence:
MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQLDVCSDESVAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFISLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQCLSCGCLPTRVRPR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity).
Catalytic Activity:
All-trans-retinol + NADP(+) = all-trans-retinal + NADPH.
Active Site:
ACT_SITE 155 155 Proton acceptor.
Cross Reference Drug Bank:
DB00162
Gene Ontology Go:
cytoplasm
integral component of plasma membrane
estradiol 17-beta-dehydrogenase activity
NADP-retinol dehydrogenase activity
retinol dehydrogenase activity
estrogen biosynthetic process
phototransduction, visible light
retinoid metabolic process
steroid biosynthetic process
visual perception
Gene Ontology Biological Process:
estrogen biosynthetic process
phototransduction, visible light
retinoid metabolic process
steroid biosynthetic process
visual perception
Gene Ontology Molecular Function:
estradiol 17-beta-dehydrogenase activity
NADP-retinol dehydrogenase activity
retinol dehydrogenase activity
Gene Ontology Cellular Component:
cytoplasm
integral component of plasma membrane
Keywords:
Complete proteome
Membrane
NADP
Oxidoreductase
Polymorphism
Reference proteome
Sensory transduction
Transmembrane
Transmembrane helix
Vision

Publication

PubMed ID:
10753906 14702039