Names & Taxonomy
- Uniprot ID:
- Q9NYR8
- Entry Name:
- RDH8_HUMAN
- Status:
- reviewed
- Protein Names:
- Retinol dehydrogenase 8 (EC 1.1.1.300) (Photoreceptor outer segment all-trans retinol dehydrogenase) (Short chain dehydrogenase/reductase family 28C member 2)
- Gene Names:
- RDH8 PRRDH SDR28C2
- Gene Names Primary:
- RDH8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 311
- Sequence:
- MAAAPRTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQLDVCSDESVAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFISLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRDLYLPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQCLSCGCLPTRVRPR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity (By similarity).
- Catalytic Activity:
- All-trans-retinol + NADP(+) = all-trans-retinal + NADPH.
- Active Site:
- ACT_SITE 155 155 Proton acceptor.
- Cross Reference Drug Bank:
- DB00162
- Gene Ontology Go:
- cytoplasm
integral component of plasma membrane
estradiol 17-beta-dehydrogenase activity
NADP-retinol dehydrogenase activity
retinol dehydrogenase activity
estrogen biosynthetic process
phototransduction, visible light
retinoid metabolic process
steroid biosynthetic process
visual perception - Gene Ontology Biological Process:
- estrogen biosynthetic process
phototransduction, visible light
retinoid metabolic process
steroid biosynthetic process
visual perception - Gene Ontology Molecular Function:
- estradiol 17-beta-dehydrogenase activity
NADP-retinol dehydrogenase activity
retinol dehydrogenase activity - Gene Ontology Cellular Component:
- cytoplasm
integral component of plasma membrane - Keywords:
- Complete proteome
Membrane
NADP
Oxidoreductase
Polymorphism
Reference proteome
Sensory transduction
Transmembrane
Transmembrane helix
Vision