Names & Taxonomy

Uniprot ID:
Q9NYK1
Entry Name:
TLR7_HUMAN
Status:
reviewed
Protein Names:
Toll-like receptor 7
Gene Names:
TLR7 UNQ248/PRO285
Gene Names Orf:
UNQ248/PRO285
Gene Names Primary:
TLR7
Organism:
Homo sapiens (Human)

Structure

Length:
1049
Sequence:
MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLKNALATDNHVAYSQVFKETV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
Cross Reference Drug Bank:
DB01611 DB00724
Gene Ontology Go:
cytoplasm
early phagosome
endolysosome membrane
endoplasmic reticulum
endoplasmic reticulum membrane
endosome
endosome membrane
Golgi membrane
integral component of membrane
lysosome
plasma membrane
receptor complex
double-stranded RNA binding
drug binding
single-stranded RNA binding
siRNA binding
transmembrane signaling receptor activity
cellular response to mechanical stimulus
defense response to virus
I-kappaB phosphorylation
inflammatory response
innate immune response
microglial cell activation
MyD88-dependent toll-like receptor signaling pathway
positive regulation of chemokine production
positive regulation of inflammatory response
positive regulation of interferon-alpha biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interferon-gamma biosynthetic process
positive regulation of interleukin-6 production
positive regulation of interleukin-8 biosynthetic process
positive regulation of interleukin-8 production
positive regulation of NF-kappaB import into nucleus
regulation of protein phosphorylation
toll-like receptor 7 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
Gene Ontology Biological Process:
cellular response to mechanical stimulus
defense response to virus
I-kappaB phosphorylation
inflammatory response
innate immune response
microglial cell activation
MyD88-dependent toll-like receptor signaling pathway
positive regulation of chemokine production
positive regulation of inflammatory response
positive regulation of interferon-alpha biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interferon-gamma biosynthetic process
positive regulation of interleukin-6 production
positive regulation of interleukin-8 biosynthetic process
positive regulation of interleukin-8 production
positive regulation of NF-kappaB import into nucleus
regulation of protein phosphorylation
toll-like receptor 7 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
Gene Ontology Molecular Function:
double-stranded RNA binding
drug binding
single-stranded RNA binding
siRNA binding
transmembrane signaling receptor activity
Gene Ontology Cellular Component:
cytoplasm
early phagosome
endolysosome membrane
endoplasmic reticulum
endoplasmic reticulum membrane
endosome
endosome membrane
Golgi membrane
integral component of membrane
lysosome
plasma membrane
receptor complex
Keywords:
Complete proteome
Cytoplasmic vesicle
Endoplasmic reticulum
Endosome
Glycoprotein
Immunity
Inflammatory response
Innate immunity
Leucine-rich repeat
Lysosome
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix

Publication

PubMed ID:
11022119 11022120 19924287 12975309 15489334 18250417