Names & Taxonomy
- Uniprot ID:
- Q9NYK1
- Entry Name:
- TLR7_HUMAN
- Status:
- reviewed
- Protein Names:
- Toll-like receptor 7
- Gene Names:
- TLR7 UNQ248/PRO285
- Gene Names Orf:
- UNQ248/PRO285
- Gene Names Primary:
- TLR7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1049
- Sequence:
- MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLKNALATDNHVAYSQVFKETV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
- Cross Reference Drug Bank:
- DB01611 DB00724
- Gene Ontology Go:
- cytoplasm
early phagosome
endolysosome membrane
endoplasmic reticulum
endoplasmic reticulum membrane
endosome
endosome membrane
Golgi membrane
integral component of membrane
lysosome
plasma membrane
receptor complex
double-stranded RNA binding
drug binding
single-stranded RNA binding
siRNA binding
transmembrane signaling receptor activity
cellular response to mechanical stimulus
defense response to virus
I-kappaB phosphorylation
inflammatory response
innate immune response
microglial cell activation
MyD88-dependent toll-like receptor signaling pathway
positive regulation of chemokine production
positive regulation of inflammatory response
positive regulation of interferon-alpha biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interferon-gamma biosynthetic process
positive regulation of interleukin-6 production
positive regulation of interleukin-8 biosynthetic process
positive regulation of interleukin-8 production
positive regulation of NF-kappaB import into nucleus
regulation of protein phosphorylation
toll-like receptor 7 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway - Gene Ontology Biological Process:
- cellular response to mechanical stimulus
defense response to virus
I-kappaB phosphorylation
inflammatory response
innate immune response
microglial cell activation
MyD88-dependent toll-like receptor signaling pathway
positive regulation of chemokine production
positive regulation of inflammatory response
positive regulation of interferon-alpha biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interferon-gamma biosynthetic process
positive regulation of interleukin-6 production
positive regulation of interleukin-8 biosynthetic process
positive regulation of interleukin-8 production
positive regulation of NF-kappaB import into nucleus
regulation of protein phosphorylation
toll-like receptor 7 signaling pathway
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway - Gene Ontology Molecular Function:
- double-stranded RNA binding
drug binding
single-stranded RNA binding
siRNA binding
transmembrane signaling receptor activity - Gene Ontology Cellular Component:
- cytoplasm
early phagosome
endolysosome membrane
endoplasmic reticulum
endoplasmic reticulum membrane
endosome
endosome membrane
Golgi membrane
integral component of membrane
lysosome
plasma membrane
receptor complex - Keywords:
- Complete proteome
Cytoplasmic vesicle
Endoplasmic reticulum
Endosome
Glycoprotein
Immunity
Inflammatory response
Innate immunity
Leucine-rich repeat
Lysosome
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix