Names & Taxonomy
- Uniprot ID:
- Q9NYJ7
- Entry Name:
- DLL3_HUMAN
- Status:
- reviewed
- Protein Names:
- Delta-like protein 3 (Drosophila Delta homolog 3) (Delta3)
- Gene Names:
- DLL3
- Gene Names Primary:
- DLL3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 618
- Sequence:
- MVSPRMSGLLSQTVILALIFLPQTRPAGVFELQIHSFGPGPGPGAPRSPCSARLPCRLFFRVCLKPGLSEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPDGLLQVPFRDAWPGTFSFIIETWREELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASALPAAPPGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVRRRGHSQDAGSRLLAGTPEPSVHALPDALNNLRTQEGSGDGPSSSVDWNRPEDVDPQGIYVISAPSIYAREVATPLFPPLHTGRAGQRQHLLFPYPSSILSVK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).
- Gene Ontology Go:
- integral component of membrane
Notch binding
compartment pattern specification
negative regulation of neurogenesis
Notch signaling pathway
paraxial mesoderm development
skeletal system development
somitogenesis - Gene Ontology Biological Process:
- compartment pattern specification
negative regulation of neurogenesis
Notch signaling pathway
paraxial mesoderm development
skeletal system development
somitogenesis - Gene Ontology Molecular Function:
- Notch binding
- Gene Ontology Cellular Component:
- integral component of membrane
- Keywords:
- Alternative splicing
Complete proteome
Developmental protein
Differentiation
Disease mutation
Disulfide bond
Dwarfism
EGF-like domain
Membrane
Notch signaling pathway
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix
Ubl conjugation