Names & Taxonomy
- Uniprot ID:
- Q9NYB5
- Entry Name:
- SO1C1_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier organic anion transporter family member 1C1 (Organic anion transporter F) (OATP-F) (Organic anion transporter polypeptide-related protein 5) (OAT-RP-5) (OATPRP5) (Organic anion-transporting polypeptide 14) (OATP-14) (Solute carrier family 21 member 14) (Thyroxine transporter)
- Gene Names:
- SLCO1C1 OATP14 OATP1C1 OATPF SLC21A14
- Gene Names Primary:
- SLCO1C1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 712
- Sequence:
- MDTSSKENIQLFCKTSVQPVGRPSFKTEYPSSEEKQPCCGELKVFLCALSFVYFAKALAEGYLKSTITQIERRFDIPSSLVGVIDGSFEIGNLLVITFVSYFGAKLHRPKIIGAGCVIMGVGTLLIAMPQFFMEQYKYERYSPSSNSTLSISPCLLESSSQLPVSVMEKSKSKISNECEVDTSSSMWIYVFLGNLLRGIGETPIQPLGIAYLDDFASEDNAAFYIGCVQTVAIIGPIFGFLLGSLCAKLYVDIGFVNLDHITITPKDPQWVGAWWLGYLIAGIISLLAAVPFWYLPKSLPRSQSREDSNSSSEKSKFIIDDHTDYQTPQGENAKIMEMARDFLPSLKNLFGNPVYFLYLCTSTVQFNSLFGMVTYKPKYIEQQYGQSSSRANFVIGLINIPAVALGIFSGGIVMKKFRISVCGAAKLYLGSSVFGYLLFLSLFALGCENSDVAGLTVSYQGTKPVSYHERALFSDCNSRCKCSETKWEPMCGENGITYVSACLAGCQTSNRSGKNIIFYNCTCVGIAASKSGNSSGIVGRCQKDNGCPQMFLYFLVISVITSYTLSLGGIPGYILLLRCIKPQLKSFALGIYTLAIRVLAGIPAPVYFGVLIDTSCLKWGFKRCGSRGSCRLYDSNVFRHIYLGLTVILGTVSILLSIAVLFILKKNYVSKHRSFITKRERTMVSTRFQKENYTTSDHLLQPNYWPGKETQL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity).
- Cross Reference Drug Bank:
- DB00286 DB00509 DB00586 DB00390 DB00917 DB00783 DB00451 DB00279 DB01583 DB00939 DB00563 DB01092 DB00252 DB01032
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
bile acid transmembrane transporter activity
sodium-independent organic anion transmembrane transporter activity
thyroid hormone transmembrane transporter activity
bile acid metabolic process
sodium-independent organic anion transport
transmembrane transport - Gene Ontology Biological Process:
- bile acid metabolic process
sodium-independent organic anion transport
transmembrane transport - Gene Ontology Molecular Function:
- bile acid transmembrane transporter activity
sodium-independent organic anion transmembrane transporter activity
thyroid hormone transmembrane transporter activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion transport
Membrane
Reference proteome
Transmembrane
Transmembrane helix
Transport