Names & Taxonomy

Uniprot ID:
Q9NY47
Entry Name:
CA2D2_HUMAN
Status:
reviewed
Protein Names:
Voltage-dependent calcium channel subunit alpha-2/delta-2 (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2]
Gene Names:
CACNA2D2 KIAA0558
Gene Names Primary:
CACNA2D2
Organism:
Homo sapiens (Human)

Structure

Length:
1150
Sequence:
MAVPARTCGASRPGPARTARPWPGCGPHPGPGTRRPTSGPPRPLWLLLPLLPLLAAPGASAYSFPQQHTMQHWARRLEQEVDGVMRIFGGVQQLREIYKDNRNLFEVQENEPQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELDDPESEDVERGSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGSTVILNELNWTEALENVFMENRRQDPTLLWQVFGSATGVTRYYPATPWRAPKKIDLYDVRRRPWYIQGASSPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPVSCFTHLVQANVRNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITRANCNKMIMMFTDGGEDRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQEYLDVLGRPMVLAGKEAKQVQWTNVYEDALGLGLVVTGTLPVFNLTQDGPGEKKNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTNFREPVTLDFLDAELEDENKEEIRRSMIDGNKGHKQIRTLVKSLDERYIDEVTRNYTWVPIRSTNYSLGLVLPPYSTFYLQANLSDQILQVKLPISKLKDFEFLLPSSFESEGHVFIAPREYCKDLNASDNNTEFLKNFIELMEKVTPDSKQCNNFLLHNLILDTGITQQLVERVWRDQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEPFNASFYRRSLDNHGYVFKPPHQDALLRPLELENDTVGILVSTAVELSLGRRTLRPAVVGVKLDLEAWAEKFKVLASNRTHQDQPQKCGPNSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLALYNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVADFLNLAWWTSAAAWSLFQQLLYGLIYHSWFQADPAEAEGSPETRESSCVMKQTQYYFGSVNASYNAIIDCGNCSRLFHAQRLTNTNLLFVVAEKPLCSQCEAGRLLQKETHSDGPEQCELVQRPRYRRGPHICFDYNATEDTSDCGRGASFPPSLGVLVSLQLLLLLGLPPRPQPQVLVHASRRL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.
Cross Reference Drug Bank:
DB01118 DB01244 DB01023 DB00996 DB00270 DB01054 DB00421
Gene Ontology Go:
plasma membrane
voltage-gated calcium channel complex
metal ion binding
voltage-gated calcium channel activity
cardiac conduction
energy reserve metabolic process
muscle fiber development
neuromuscular junction development
positive regulation of organ growth
regulation of insulin secretion
regulation of multicellular organism growth
rhythmic synaptic transmission
small molecule metabolic process
Gene Ontology Biological Process:
cardiac conduction
energy reserve metabolic process
muscle fiber development
neuromuscular junction development
positive regulation of organ growth
regulation of insulin secretion
regulation of multicellular organism growth
rhythmic synaptic transmission
small molecule metabolic process
Gene Ontology Molecular Function:
metal ion binding
voltage-gated calcium channel activity
Gene Ontology Cellular Component:
plasma membrane
voltage-gated calcium channel complex
Keywords:
Alternative splicing
Calcium
Calcium channel
Calcium transport
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Membrane
Metal-binding
Polymorphism
Reference proteome
Signal
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel

Publication

PubMed ID:
9880589 10766861 10762351 9628581 16641997 15489334 11687876 15000524 12555074 15111129 19349973