Names & Taxonomy
- Uniprot ID:
- Q9NXE4
- Entry Name:
- NSMA3_HUMAN
- Status:
- reviewed
- Protein Names:
- Sphingomyelin phosphodiesterase 4 (EC 3.1.4.12) (Neutral sphingomyelinase 3) (nSMase-3) (nSMase3) (Neutral sphingomyelinase III)
- Gene Names:
- SMPD4 KIAA1418
- Gene Names Primary:
- SMPD4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 827
- Sequence:
- MAFPHLQQPSFLLASLKADSINKPFAQQCQDLVKVIEDFPAKELHTIFPWLVESIFGSLDGVLVGWNLRCLQGRVNPVEYSIVMEFLDPGGPMMKLVYKLQAEDYKFDFPVSYLPGPVKASIQECILPDSPLYHNKVQFTPTGGLGLNLALNPFEYYIFFFALSLITQKPLPVSLHVRTSDCAYFILVDRYLSWFLPTEGSVPPPLSSSPGGTSPSPPPRTPAIPFASYGLHHTSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAKLEVLHYRLSVSSALYSPAQPSLQALHAYQESFTPTEEHVLVVRLLLKHLHAFANSLKPEQASPSAHSHATSPLEEFKRAAVPRFVQQKLYLFLQHCFGHWPLDASFRAVLEMWLSYLQPWRYAPDKQAPGSDSQPRCVSEKWAPFVQENLLMYTKLFVGFLNRALRTDLVSPKHALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELVIPHRQHRLFTAPTFTGSFLSPWPPAVTDASFKVKSHVYSLEGQDCKYTPMFGPEARTLVLRLAQLITQAKHTAKSISDQCAESPAGHSFLSWLGFSSMDTNGSYTANDLDEMGQDSVRKTDEYLEKALEYLRQIFRLSEAQLRQFTLALGTTQDENGKKQLPDCIVGEDGLILTPLGRYQIINGLRRFEIEYQGDPELQPIRSYEIASLVRTLFRLSSAINHRFAGQMAALCSRDDFLGSFCRYHLTEPGLASRHLLSPVGRRQVAGHTRGPRLSLRFLGSYRTLVSLLLAFFVASLFCVGPLPCTLLLTLGYVLYASAMTLLTERGKLHQP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide.
- Catalytic Activity:
- Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Enzyme Regulation:
- ENZYME REGULATION: Activated by phosphatidylserine and tumor necrosis factor (TNF). Inhibited by scyphostatin.
- Cross Reference Drug Bank:
- DB00144
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
Golgi apparatus
Golgi membrane
integral component of membrane
trans-Golgi network
metal ion binding
sphingomyelin phosphodiesterase activity
sphingomyelin phosphodiesterase D activity
cellular response to tumor necrosis factor
ceramide biosynthetic process
glycerophospholipid catabolic process
glycosphingolipid metabolic process
small molecule metabolic process
sphingolipid metabolic process
sphingomyelin catabolic process - Gene Ontology Biological Process:
- cellular response to tumor necrosis factor
ceramide biosynthetic process
glycerophospholipid catabolic process
glycosphingolipid metabolic process
small molecule metabolic process
sphingolipid metabolic process
sphingomyelin catabolic process - Gene Ontology Molecular Function:
- metal ion binding
sphingomyelin phosphodiesterase activity
sphingomyelin phosphodiesterase D activity - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
Golgi apparatus
Golgi membrane
integral component of membrane
trans-Golgi network - Keywords:
- Alternative splicing
Complete proteome
Endoplasmic reticulum
Golgi apparatus
Hydrolase
Magnesium
Membrane
Metal-binding
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix