Names & Taxonomy
- Uniprot ID:
- Q9NSD5
- Entry Name:
- S6A13_HUMAN
- Status:
- reviewed
- Protein Names:
- Sodium- and chloride-dependent GABA transporter 2 (GAT-2) (Solute carrier family 6 member 13)
- Gene Names:
- SLC6A13 GAT2
- Gene Names Primary:
- SLC6A13
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 602
- Sequence:
- MDSRVSGTTSNGETKPVYPVMEKKEEDGTLERGHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLNVYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCMEFQKTNGSLNGTSENATSPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWLFLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRERIRQLMCPAEDLPQRNPAGPSAPATPRTSLLRLTELESHC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=3.7 uM for GABA
- Gene Ontology Go:
- extracellular exosome
integral component of plasma membrane
neuron projection
plasma membrane
presynapse
gamma-aminobutyric acid:sodium symporter activity
neurotransmitter binding
neurotransmitter:sodium symporter activity
gamma-aminobutyric acid transport
neurotransmitter secretion
neurotransmitter transport
synaptic transmission
transmembrane transport - Gene Ontology Biological Process:
- gamma-aminobutyric acid transport
neurotransmitter secretion
neurotransmitter transport
synaptic transmission
transmembrane transport - Gene Ontology Molecular Function:
- gamma-aminobutyric acid:sodium symporter activity
neurotransmitter:sodium symporter activity
neurotransmitter binding - Gene Ontology Cellular Component:
- extracellular exosome
integral component of plasma membrane
neuron projection
plasma membrane
presynapse - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Membrane
Neurotransmitter transport
Phosphoprotein
Polymorphism
Reference proteome
Symport
Transmembrane
Transmembrane helix
Transport