Names & Taxonomy
- Uniprot ID:
- Q9NSA2
- Entry Name:
- KCND1_HUMAN
- Status:
- reviewed
- Protein Names:
- Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1)
- Gene Names:
- KCND1
- Gene Names Primary:
- KCND1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 647
- Sequence:
- MAAGLATWLPFARAAAVGWLPLAQQPLPPAPGVKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGDGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLLVPKNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNGGLEDSGSGEEQALCVRNRSAFEQQHHHLLHCLEKTTCHEFTDELTFSEALGAVSPGGRTSRSTSVSSQPVGPGSLLSSCCPRRAKRRAIRLANSTASVSRGSMQELDMLAGLRRSHAPQSRSSLNAKPHDSLDLNCDSRDFVAAIISIPTPPANTPDESQPSSPGGGGRAGSTLRNSSLGTPCLFPETVKISSL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein. Cell projection, dendrite
- Intramembrane:
- INTRAMEM 365 385 Pore-forming; Name=Segment H5.
Function
- Function:
- Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
- Cross Reference Drug Bank:
- DB06637
- Gene Ontology Go:
- dendrite
integral component of membrane
neuronal cell body
plasma membrane
voltage-gated potassium channel complex
A-type (transient outward) potassium channel activity
metal ion binding
cardiac conduction
protein homooligomerization
synaptic transmission - Gene Ontology Biological Process:
- cardiac conduction
protein homooligomerization
synaptic transmission - Gene Ontology Molecular Function:
- A-type (transient outward) potassium channel activity
metal ion binding - Gene Ontology Cellular Component:
- dendrite
integral component of membrane
neuronal cell body
plasma membrane
voltage-gated potassium channel complex - Keywords:
- Alternative splicing
Cell projection
Complete proteome
Glycoprotein
Ion channel
Ion transport
Membrane
Metal-binding
Phosphoprotein
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel
Zinc