Names & Taxonomy
- Uniprot ID:
- Q9NR96
- Entry Name:
- TLR9_HUMAN
- Status:
- reviewed
- Protein Names:
- Toll-like receptor 9 (CD antigen CD289)
- Gene Names:
- TLR9 UNQ5798/PRO19605
- Gene Names Orf:
- UNQ5798/PRO19605
- Gene Names Primary:
- TLR9
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1032
- Sequence:
- MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHFYNRNFCQGPTAE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.
- Cross Reference Drug Bank:
- DB00608 DB01611
- Gene Ontology Go:
- apical plasma membrane
basolateral plasma membrane
cytoplasm
early phagosome
endolysosome membrane
endoplasmic reticulum
endoplasmic reticulum membrane
endosome
endosome membrane
extracellular region
Golgi membrane
integral component of membrane
lysosome
plasma membrane
interleukin-1 receptor binding
siRNA binding
transmembrane signaling receptor activity
defense response to bacterium
defense response to Gram-negative bacterium
I-kappaB phosphorylation
inflammatory response
innate immune response
insulin receptor signaling pathway
maintenance of gastrointestinal epithelium
MyD88-dependent toll-like receptor signaling pathway
negative regulation of calcium-transporting ATPase activity
negative regulation of interleukin-6 production
negative regulation of interleukin-8 production
negative regulation of NF-kappaB transcription factor activity
negative regulation of toll-like receptor signaling pathway
positive regulation of chemokine production
positive regulation of gene expression
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of inflammatory response
positive regulation of interferon-alpha biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interferon-beta production
positive regulation of interferon-gamma biosynthetic process
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-18 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of JNK cascade
positive regulation of JUN kinase activity
positive regulation of NF-kappaB import into nucleus
positive regulation of NF-kappaB transcription factor activity
positive regulation of nitric-oxide synthase biosynthetic process
positive regulation of toll-like receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of tumor necrosis factor production
regulation of cytokine secretion
response to molecule of bacterial origin
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
tumor necrosis factor production - Gene Ontology Biological Process:
- defense response to bacterium
defense response to Gram-negative bacterium
I-kappaB phosphorylation
inflammatory response
innate immune response
insulin receptor signaling pathway
maintenance of gastrointestinal epithelium
MyD88-dependent toll-like receptor signaling pathway
negative regulation of calcium-transporting ATPase activity
negative regulation of interleukin-6 production
negative regulation of interleukin-8 production
negative regulation of NF-kappaB transcription factor activity
negative regulation of toll-like receptor signaling pathway
positive regulation of chemokine production
positive regulation of gene expression
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of inflammatory response
positive regulation of interferon-alpha biosynthetic process
positive regulation of interferon-beta biosynthetic process
positive regulation of interferon-beta production
positive regulation of interferon-gamma biosynthetic process
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-18 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of JNK cascade
positive regulation of JUN kinase activity
positive regulation of NF-kappaB import into nucleus
positive regulation of NF-kappaB transcription factor activity
positive regulation of nitric-oxide synthase biosynthetic process
positive regulation of toll-like receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of tumor necrosis factor production
regulation of cytokine secretion
response to molecule of bacterial origin
toll-like receptor 9 signaling pathway
toll-like receptor signaling pathway
tumor necrosis factor production - Gene Ontology Molecular Function:
- interleukin-1 receptor binding
siRNA binding
transmembrane signaling receptor activity - Gene Ontology Cellular Component:
- apical plasma membrane
basolateral plasma membrane
cytoplasm
early phagosome
endolysosome membrane
endoplasmic reticulum
endoplasmic reticulum membrane
endosome
endosome membrane
extracellular region
Golgi membrane
integral component of membrane
lysosome
plasma membrane - Keywords:
- Alternative splicing
Complete proteome
Cytoplasmic vesicle
Endoplasmic reticulum
Endosome
Glycoprotein
Immunity
Inflammatory response
Innate immunity
Leucine-rich repeat
Lysosome
Membrane
Polymorphism
Receptor
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix