Names & Taxonomy
- Uniprot ID:
- Q9NR33
- Entry Name:
- DPOE4_HUMAN
- Status:
- reviewed
- Protein Names:
- DNA polymerase epsilon subunit 4 (EC 2.7.7.7) (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12)
- Gene Names:
- POLE4
- Gene Names Primary:
- POLE4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 117
- Sequence:
- MAAAAAAGSGTPREEEGPAGEAAASQPQAPTSVPGARLSRLPLARVKALVKADPDVTLAGQEAIFILARAAELFVETIAKDAYCCAQQGKRKTLQRRDLDNAIEAVDEFAFLEGTLD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus
Function
- Function:
- May play a role in allowing polymerase epsilon to carry out its replication and/or repair function.
- Catalytic Activity:
- Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
- Cross Reference Drug Bank:
- DB00242
- Gene Ontology Go:
- Ada2/Gcn5/Ada3 transcription activator complex
epsilon DNA polymerase complex
nucleus
DNA binding
DNA-directed DNA polymerase activity
DNA biosynthetic process
histone H3 acetylation - Gene Ontology Biological Process:
- DNA biosynthetic process
histone H3 acetylation - Gene Ontology Molecular Function:
- DNA binding
DNA-directed DNA polymerase activity - Gene Ontology Cellular Component:
- Ada2/Gcn5/Ada3 transcription activator complex
epsilon DNA polymerase complex
nucleus - Keywords:
- Acetylation
Complete proteome
DNA-binding
DNA-directed DNA polymerase
Nucleotidyltransferase
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Transferase - Interacts With:
- P25208; Q9Q2G4; Q9NRF9