Names & Taxonomy
- Uniprot ID:
- Q9NQ11
- Entry Name:
- AT132_HUMAN
- Status:
- reviewed
- Protein Names:
- Probable cation-transporting ATPase 13A2 (EC 3.6.3.-)
- Gene Names:
- ATP13A2 PARK9
- Gene Names Primary:
- ATP13A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1180
- Sequence:
- MSADSSPLVGSTPTGYGTLTIGTSIDPLSSSVSSVRLSGYCGSPWRVIGYHVVVWMMAGIPLLLFRWKPLWGVRLRLRPCNLAHAETLVIEIRDKEDSSWQLFTVQVQTEAIGEGSLEPSPQSQAEDGRSQAAVGAVPEGAWKDTAQLHKSEEAVSVGQKRVLRYYLFQGQRYIWIETQQAFYQVSLLDHGRSCDDVHRSRHGLSLQDQMVRKAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISSISICLSLYKTRKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGDCLVLPQEGGLMPCDAALVAGECMVNESSLTGESIPVLKTALPEGLGPYCAETHRRHTLFCGTLILQARAYVGPHVLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYRNRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMGVVPLKGQAFLPLVPEPRRLPVGPLLRALATCHALSRLQDTPVGDPMDLKMVESTGWVLEEEPAADSAFGTQVLAVMRPPLWEPQLQAMEEPPVPVSVLHRFPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLCNPETVPTDFAQMLQSYTAAGYRVVALASKPLPTVPSLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQEHLIIVHATHPERGQPASLEFLPMESPTAVNGVKDPDQAASYTVEPDPRSRHLALSGPTFGIIVKHFPKLLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALVLGRVRPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFVPLNRTVAAPDNLPNYENTVVFSLSSFQYLILAAAVSKGAPFRRPLYTNVPFLVALALLSSVLVGLVLVPGLLQGPLALRNITDTGFKLLLLGLVTLNFVGAFMLESVLDQCLPACLRRLRPKRASKKRFKQLERELAEQPWPPLPAGPLR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity.
- Catalytic Activity:
- ATP + H(2)O = ADP + phosphate.
- Active Site:
- ACT_SITE 513 513 4-aspartylphosphate intermediate.
- Gene Ontology Go:
- integral component of membrane
integral component of plasma membrane
lysosomal lumen
lysosomal membrane
lysosome
multivesicular body
neuron projection
neuronal cell body
transport vesicle
vesicle membrane
ATP binding
ATPase activity
cation-transporting ATPase activity
metal ion binding
autophagosome organization
cation transmembrane transport
cellular calcium ion homeostasis
cellular cation homeostasis
cellular response to manganese ion
ion transmembrane transport
regulation of autophagosome size
regulation of mitochondrion organization
regulation of mitophagy
transmembrane transport - Gene Ontology Biological Process:
- autophagosome organization
cation transmembrane transport
cellular calcium ion homeostasis
cellular cation homeostasis
cellular response to manganese ion
ion transmembrane transport
regulation of autophagosome size
regulation of mitochondrion organization
regulation of mitophagy
transmembrane transport - Gene Ontology Molecular Function:
- ATPase activity
ATP binding
cation-transporting ATPase activity
metal ion binding - Gene Ontology Cellular Component:
- integral component of membrane
integral component of plasma membrane
lysosomal lumen
lysosomal membrane
lysosome
multivesicular body
neuronal cell body
neuron projection
transport vesicle
vesicle membrane - Keywords:
- ATP-binding
Alternative splicing
Complete proteome
Disease mutation
Hydrolase
Lysosome
Magnesium
Membrane
Metal-binding
Neurodegeneration
Neuronal ceroid lipofuscinosis
Nucleotide-binding
Parkinsonism
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix - Interacts With:
- Q2M2I8; O60238; O14976; Q9UBN7; P11142; Q9BT88; O95070