Names & Taxonomy

Uniprot ID:
Q9NQ11
Entry Name:
AT132_HUMAN
Status:
reviewed
Protein Names:
Probable cation-transporting ATPase 13A2 (EC 3.6.3.-)
Gene Names:
ATP13A2 PARK9
Gene Names Primary:
ATP13A2
Organism:
Homo sapiens (Human)

Structure

Length:
1180
Sequence:
MSADSSPLVGSTPTGYGTLTIGTSIDPLSSSVSSVRLSGYCGSPWRVIGYHVVVWMMAGIPLLLFRWKPLWGVRLRLRPCNLAHAETLVIEIRDKEDSSWQLFTVQVQTEAIGEGSLEPSPQSQAEDGRSQAAVGAVPEGAWKDTAQLHKSEEAVSVGQKRVLRYYLFQGQRYIWIETQQAFYQVSLLDHGRSCDDVHRSRHGLSLQDQMVRKAIYGPNVISIPVKSYPQLLVDEALNPYYGFQAFSIALWLADHYYWYALCIFLISSISICLSLYKTRKQSQTLRDMVKLSMRVCVCRPGGEEEWVDSSELVPGDCLVLPQEGGLMPCDAALVAGECMVNESSLTGESIPVLKTALPEGLGPYCAETHRRHTLFCGTLILQARAYVGPHVLAVVTRTGFCTAKGGLVSSILHPRPINFKFYKHSMKFVAALSVLALLGTIYSIFILYRNRVPLNEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRRQGIFCIHPLRINLGGKLQLVCFDKTGTLTEDGLDVMGVVPLKGQAFLPLVPEPRRLPVGPLLRALATCHALSRLQDTPVGDPMDLKMVESTGWVLEEEPAADSAFGTQVLAVMRPPLWEPQLQAMEEPPVPVSVLHRFPFSSALQRMSVVVAWPGATQPEAYVKGSPELVAGLCNPETVPTDFAQMLQSYTAAGYRVVALASKPLPTVPSLEAAQQLTRDTVEGDLSLLGLLVMRNLLKPQTTPVIQALRRTRIRAVMVTGDNLQTAVTVARGCGMVAPQEHLIIVHATHPERGQPASLEFLPMESPTAVNGVKDPDQAASYTVEPDPRSRHLALSGPTFGIIVKHFPKLLPKVLVQGTVFARMAPEQKTELVCELQKLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPMVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALVLGRVRPPGALLSVPVLSSLLLQMVLVTGVQLGGYFLTLAQPWFVPLNRTVAAPDNLPNYENTVVFSLSSFQYLILAAAVSKGAPFRRPLYTNVPFLVALALLSSVLVGLVLVPGLLQGPLALRNITDTGFKLLLLGLVTLNFVGAFMLESVLDQCLPACLRRLRPKRASKKRFKQLERELAEQPWPPLPAGPLR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity.
Catalytic Activity:
ATP + H(2)O = ADP + phosphate.
Active Site:
ACT_SITE 513 513 4-aspartylphosphate intermediate.
Gene Ontology Go:
integral component of membrane
integral component of plasma membrane
lysosomal lumen
lysosomal membrane
lysosome
multivesicular body
neuron projection
neuronal cell body
transport vesicle
vesicle membrane
ATP binding
ATPase activity
cation-transporting ATPase activity
metal ion binding
autophagosome organization
cation transmembrane transport
cellular calcium ion homeostasis
cellular cation homeostasis
cellular response to manganese ion
ion transmembrane transport
regulation of autophagosome size
regulation of mitochondrion organization
regulation of mitophagy
transmembrane transport
Gene Ontology Biological Process:
autophagosome organization
cation transmembrane transport
cellular calcium ion homeostasis
cellular cation homeostasis
cellular response to manganese ion
ion transmembrane transport
regulation of autophagosome size
regulation of mitochondrion organization
regulation of mitophagy
transmembrane transport
Gene Ontology Molecular Function:
ATPase activity
ATP binding
cation-transporting ATPase activity
metal ion binding
Gene Ontology Cellular Component:
integral component of membrane
integral component of plasma membrane
lysosomal lumen
lysosomal membrane
lysosome
multivesicular body
neuronal cell body
neuron projection
transport vesicle
vesicle membrane
Keywords:
ATP-binding
Alternative splicing
Complete proteome
Disease mutation
Hydrolase
Lysosome
Magnesium
Membrane
Metal-binding
Neurodegeneration
Neuronal ceroid lipofuscinosis
Nucleotide-binding
Parkinsonism
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Interacts With:
Q2M2I8; O60238; O14976; Q9UBN7; P11142; Q9BT88; O95070

Publication

PubMed ID:
14702039 16710414 15489334 17974005 16964263 20683840 21542062 22186024 17485642 18413573 19015489 19085912 20853184 22388936