Names & Taxonomy
- Uniprot ID:
- Q9NPB1
- Entry Name:
- NT5M_HUMAN
- Status:
- reviewed
- Protein Names:
- 5'(3')-deoxyribonucleotidase, mitochondrial (5',3'-nucleotidase, mitochondrial) (EC 3.1.3.-) (Deoxy-5'-nucleotidase 2) (dNT-2)
- Gene Names:
- NT5M DNT2
- Gene Names Primary:
- NT5M
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 228
- Sequence:
- MIRLGGWCARRLCSAAVPAGRRGAAGGLGLAGGRALRVLVDMDGVLADFEGGFLRKFRARFPDQPFIALEDRRGFWVSEQYGRLRPGLSEKAISIWESKNFFFELEPLPGAVEAVKEMASLQNTDVFICTSPIKMFKYCPYEKYAWVEKYFGPDFLEQIVLTRDKTVVSADLLIDDRPDITGAEPTPSWEHVLFTACHNQHLQLQPPRRRLHSWADDWKAILDSKRPC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion
Function
- Function:
- Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 41 41 Nucleophile.; ACT_SITE 43 43 Proton donor.
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
5'-nucleotidase activity
metal ion binding
nucleotidase activity
nucleotide binding
dephosphorylation
DNA replication
dUMP catabolic process
nucleobase-containing small molecule metabolic process
pyrimidine deoxyribonucleotide catabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
small molecule metabolic process - Gene Ontology Biological Process:
- dephosphorylation
DNA replication
dUMP catabolic process
nucleobase-containing small molecule metabolic process
pyrimidine deoxyribonucleotide catabolic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside catabolic process
small molecule metabolic process - Gene Ontology Molecular Function:
- 5'-nucleotidase activity
metal ion binding
nucleotidase activity
nucleotide binding - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion - Keywords:
- 3D-structure
Complete proteome
Hydrolase
Magnesium
Metal-binding
Mitochondrion
Nucleotide metabolism
Nucleotide-binding
Reference proteome
Transit peptide