Names & Taxonomy

Uniprot ID:
Q9NPA1
Entry Name:
KCMB3_HUMAN
Status:
reviewed
Protein Names:
Calcium-activated potassium channel subunit beta-3 (BK channel subunit beta-3) (BKbeta3) (Hbeta3) (Calcium-activated potassium channel, subfamily M subunit beta-3) (Charybdotoxin receptor subunit beta-3) (K(VCA)beta-3) (Maxi K channel subunit beta-3) (Slo-beta-3)
Gene Names:
KCNMB3 KCNMB2 KCNMBL
Gene Names Primary:
KCNMB3
Organism:
Homo sapiens (Human)

Structure

Length:
279
Sequence:
MDFSPSSELGFHFVAFILLTRHRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLGFAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGTPFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKYSTVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane; Multi-pass membrane protein.

Function

Function:
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.
Cross Reference Drug Bank:
DB01110 DB00721
Gene Ontology Go:
integral component of plasma membrane
plasma membrane
voltage-gated potassium channel complex
calcium-activated potassium channel activity
potassium channel regulator activity
action potential
blood coagulation
detection of calcium ion
neuronal action potential
potassium ion transmembrane transport
potassium ion transport
synaptic transmission
Gene Ontology Biological Process:
action potential
blood coagulation
detection of calcium ion
neuronal action potential
potassium ion transmembrane transport
potassium ion transport
synaptic transmission
Gene Ontology Molecular Function:
calcium-activated potassium channel activity
potassium channel regulator activity
Gene Ontology Cellular Component:
integral component of plasma membrane
plasma membrane
voltage-gated potassium channel complex
Keywords:
Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Ion channel
Ion transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
10585773 10692449 10766764 10792058 10828459 14702039 16641997 10864947 11382808 11382809 14612589 12740608 12136044