Names & Taxonomy
- Uniprot ID:
- Q9NP99
- Entry Name:
- TREM1_HUMAN
- Status:
- reviewed
- Protein Names:
- Triggering receptor expressed on myeloid cells 1 (TREM-1) (Triggering receptor expressed on monocytes 1) (CD antigen CD354)
- Gene Names:
- TREM1
- Gene Names Primary:
- TREM1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 234
- Sequence:
- MRKTRLWGLLWMLFVSELRAATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPKEPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPRTVTQAPPKSTADVSTPDSEINLTNVTDIIRVPVFNIVILLAGGFLSKSLVFSVLFAVTLRSFVP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane
Function
- Function:
- Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.
- Gene Ontology Go:
- extracellular region
integral component of membrane
intracellular
plasma membrane
receptor activity
scaffold protein binding
blood coagulation
chemokine metabolic process
cytokine secretion involved in immune response
humoral immune response
innate immune response
intracellular signal transduction
leukocyte migration
mitophagy in response to mitochondrial depolarization
neutrophil chemotaxis
neutrophil extravasation
neutrophil mediated killing of gram-negative bacterium
positive regulation of defense response to virus by host
regulation of immune response
xenophagy - Gene Ontology Biological Process:
- blood coagulation
chemokine metabolic process
cytokine secretion involved in immune response
humoral immune response
innate immune response
intracellular signal transduction
leukocyte migration
mitophagy in response to mitochondrial depolarization
neutrophil chemotaxis
neutrophil extravasation
neutrophil mediated killing of gram-negative bacterium
positive regulation of defense response to virus by host
regulation of immune response
xenophagy - Gene Ontology Molecular Function:
- receptor activity
scaffold protein binding - Gene Ontology Cellular Component:
- extracellular region
integral component of membrane
intracellular
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Polymorphism
Receptor
Reference proteome
Secreted
Signal
Transmembrane
Transmembrane helix