Names & Taxonomy

Uniprot ID:
Q9NP78
Entry Name:
ABCB9_HUMAN
Status:
reviewed
Protein Names:
ATP-binding cassette sub-family B member 9 (ATP-binding cassette transporter 9) (ABC transporter 9 protein) (hABCB9) (TAP-like protein) (TAPL)
Gene Names:
ABCB9 KIAA1520
Gene Names Primary:
ABCB9
Organism:
Homo sapiens (Human)

Structure

Length:
766
Sequence:
MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCLLLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALFVWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Lysosome membrane

Function

Function:
ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=6.8 uM for peptide RRYQNSTCL
Gene Ontology Go:
integral component of endoplasmic reticulum membrane
integral component of membrane
lysosomal membrane
lysosome
ATP binding
oligopeptide-transporting ATPase activity
peptide-transporting ATPase activity
protein homodimerization activity
substrate-specific transmembrane transporter activity
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
oligopeptide transmembrane transport
peptide transport
positive regulation of antigen processing and presentation of peptide antigen via MHC class I
protein transport
transmembrane transport
Gene Ontology Biological Process:
antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
oligopeptide transmembrane transport
peptide transport
positive regulation of antigen processing and presentation of peptide antigen via MHC class I
protein transport
transmembrane transport
Gene Ontology Molecular Function:
ATP binding
oligopeptide-transporting ATPase activity
peptide-transporting ATPase activity
protein homodimerization activity
substrate-specific transmembrane transporter activity
Gene Ontology Cellular Component:
integral component of endoplasmic reticulum membrane
integral component of membrane
lysosomal membrane
lysosome
Keywords:
ATP-binding
Alternative splicing
Complete proteome
Lysosome
Membrane
Nucleotide-binding
Peptide transport
Polymorphism
Protein transport
Reference proteome
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
11011155 10748049 13679046 15491607 10819331 14702039 16541075 15489334 15577206 15863492 17977821 17897319 18952056 18175933 18434309 20377823 21212514 11829140