Names & Taxonomy
- Uniprot ID:
- Q9NP78
- Entry Name:
- ABCB9_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP-binding cassette sub-family B member 9 (ATP-binding cassette transporter 9) (ABC transporter 9 protein) (hABCB9) (TAP-like protein) (TAPL)
- Gene Names:
- ABCB9 KIAA1520
- Gene Names Primary:
- ABCB9
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 766
- Sequence:
- MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCLLLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALFVWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Lysosome membrane
Function
- Function:
- ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=6.8 uM for peptide RRYQNSTCL
- Gene Ontology Go:
- integral component of endoplasmic reticulum membrane
integral component of membrane
lysosomal membrane
lysosome
ATP binding
oligopeptide-transporting ATPase activity
peptide-transporting ATPase activity
protein homodimerization activity
substrate-specific transmembrane transporter activity
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
oligopeptide transmembrane transport
peptide transport
positive regulation of antigen processing and presentation of peptide antigen via MHC class I
protein transport
transmembrane transport - Gene Ontology Biological Process:
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
oligopeptide transmembrane transport
peptide transport
positive regulation of antigen processing and presentation of peptide antigen via MHC class I
protein transport
transmembrane transport - Gene Ontology Molecular Function:
- ATP binding
oligopeptide-transporting ATPase activity
peptide-transporting ATPase activity
protein homodimerization activity
substrate-specific transmembrane transporter activity - Gene Ontology Cellular Component:
- integral component of endoplasmic reticulum membrane
integral component of membrane
lysosomal membrane
lysosome - Keywords:
- ATP-binding
Alternative splicing
Complete proteome
Lysosome
Membrane
Nucleotide-binding
Peptide transport
Polymorphism
Protein transport
Reference proteome
Transmembrane
Transmembrane helix
Transport