Names & Taxonomy
- Uniprot ID:
- Q9NP59
- Entry Name:
- S40A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1)
- Gene Names:
- SLC40A1 FPN1 IREG1 SLC11A3 MSTP079
- Gene Names Orf:
- MSTP079
- Gene Names Primary:
- SLC40A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 571
- Sequence:
- MTRAGDHNRQRGCCGSLADYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKHELLTMYHGWVLTSCYILIITIANIANLASTATAITIQRDWIVVVAGEDRSKLANMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYVLLWKVYQKTPALAVKAGLKEEETELKQLNLHKDTEPKPLEGTHLMGVKDSNIHELEHEQEPTCASQMAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSILMGASAITGIMGTVAFTWLRRKCGLVRTGLISGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIQGESITPTKIPEITTEIYMSNGSNSANIVPETSPESVPIISVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHIMYFRFAQNTLGNKLFACGPDAKEVRKENQANTSVV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).
- Gene Ontology Go:
- basolateral plasma membrane
cytoplasm
integral component of membrane
integral component of plasma membrane
intracellular
multivesicular body
plasma membrane
synaptic vesicle
ferrous iron transmembrane transporter activity
iron channel activity
iron ion transmembrane transporter activity
peptide hormone binding
receptor activity
cellular iron ion homeostasis
endothelium development
ferrous iron export
iron ion transmembrane transport
lymphocyte homeostasis
multicellular organismal iron ion homeostasis
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter in response to iron
spleen trabecula formation
transmembrane transport - Gene Ontology Biological Process:
- cellular iron ion homeostasis
endothelium development
ferrous iron export
iron ion transmembrane transport
lymphocyte homeostasis
multicellular organismal iron ion homeostasis
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription from RNA polymerase II promoter in response to iron
spleen trabecula formation
transmembrane transport - Gene Ontology Molecular Function:
- ferrous iron transmembrane transporter activity
iron channel activity
iron ion transmembrane transporter activity
peptide hormone binding
receptor activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
cytoplasm
integral component of membrane
integral component of plasma membrane
intracellular
multivesicular body
plasma membrane
synaptic vesicle - Keywords:
- Cell membrane
Complete proteome
Disease mutation
Glycoprotein
Ion transport
Iron
Iron transport
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport - Interacts With:
- P05067