Names & Taxonomy
- Uniprot ID:
- Q9HD20
- Entry Name:
- AT131_HUMAN
- Status:
- reviewed
- Protein Names:
- Manganese-transporting ATPase 13A1 (EC 3.6.3.-)
- Gene Names:
- ATP13A1 ATP13A KIAA1825 CGI-152
- Gene Names Orf:
- CGI-152
- Gene Names Primary:
- ATP13A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1204
- Sequence:
- MAAAAAVGNAVPCGARPCGVRPDGQPKPGPQPRALLAAGPALIANGDELVAAVWPYRRLALLRRLTVLPFAGLLYPAWLGAAAAGCWGWGSSWVQIPEAALLVLATICLAHALTVLSGHWSVHAHCALTCTPEYDPSKATFVKVVPTPNNGSTELVALHRNEGEDGLEVLSFEFQKIKYSYDALEKKQFLPVAFPVGNAFSYYQSNRGFQEDSEIRAAEKKFGSNKAEMVVPDFSELFKERATAPFFVFQVFCVGLWCLDEYWYYSVFTLSMLVAFEASLVQQQMRNMSEIRKMGNKPHMIQVYRSRKWRPIASDEIVPGDIVSIGRSPQENLVPCDVLLLRGRCIVDEAMLTGESVPQMKEPIEDLSPDRVLDLQADSRLHVIFGGTKVVQHIPPQKATTGLKPVDSGCVAYVLRTGFNTSQGKLLRTILFGVKRVTANNLETFIFILFLLVFAIAAAAYVWIEGTKDPSRNRYKLFLECTLILTSVVPPELPIELSLAVNTSLIALAKLYMYCTEPFRIPFAGKVEVCCFDKTGTLTSDSLVVRGVAGLRDGKEVTPVSSIPVETHRALASCHSLMQLDDGTLVGDPLEKAMLTAVDWTLTKDEKVFPRSIKTQGLKIHQRFHFASALKRMSVLASYEKLGSTDLCYIAAVKGAPETLHSMFSQCPPDYHHIHTEISREGARVLALGYKELGHLTHQQAREVKREALECSLKFVGFIVVSCPLKADSKAVIREIQNASHRVVMITGDNPLTACHVAQELHFIEKAHTLILQPPSEKGRQCEWRSIDGSIVLPLARGSPKALALEYALCLTGDGLAHLQATDPQQLLRLIPHVQVFARVAPKQKEFVITSLKELGYVTLMCGDGTNDVGALKHADVGVALLANAPERVVERRRRPRDSPTLSNSGIRATSRTAKQRSGLPPSEEQPTSQRDRLSQVLRDLEDESTPIVKLGDASIAAPFTSKLSSIQCICHVIKQGRCTLVTTLQMFKILALNALILAYSQSVLYLEGVKFSDFQATLQGLLLAGCFLFISRSKPLKTLSRERPLPNIFNLYTILTVMLQFFVHFLSLVYLYREAQARSPEKQEQFVDLYKEFEPSLVNSTVYIMAMAMQMATFAINYKGPPFMESLPENKPLVWSLAVSLLAIIGLLLGSSPDFNSQFGLVDIPVEFKLVIAQVLLLDFCLALLADRVLQFFLGTPKLKVPS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis.
- Catalytic Activity:
- ATP + H(2)O = ADP + phosphate.
- Active Site:
- ACT_SITE 533 533 4-aspartylphosphate intermediate.
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of plasma membrane
intracellular membrane-bounded organelle
membrane
ATP binding
cation-transporting ATPase activity
metal ion binding
cation transmembrane transport
cellular calcium ion homeostasis
ion transmembrane transport
transmembrane transport - Gene Ontology Biological Process:
- cation transmembrane transport
cellular calcium ion homeostasis
ion transmembrane transport
transmembrane transport - Gene Ontology Molecular Function:
- ATP binding
cation-transporting ATPase activity
metal ion binding - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of plasma membrane
intracellular membrane-bounded organelle
membrane - Keywords:
- ATP-binding
Acetylation
Alternative splicing
Complete proteome
Endoplasmic reticulum
Glycoprotein
Hydrolase
Magnesium
Manganese
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix
Transport