Names & Taxonomy

Uniprot ID:
Q9HCS2
Entry Name:
CP4FC_HUMAN
Status:
reviewed
Protein Names:
Cytochrome P450 4F12 (EC 1.14.14.1) (CYPIVF12)
Gene Names:
CYP4F12 UNQ568/PRO1129
Gene Names Orf:
UNQ568/PRO1129
Gene Names Primary:
CYP4F12
Organism:
Homo sapiens (Human)

Structure

Length:
524
Sequence:
MSLLSLPWLGLRPVATSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGLKNSTQMSATYSQGFTIWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSCLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Endoplasmic reticulum membrane

Function

Function:
Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine.
Catalytic Activity:
RH + + O(2) = ROH + + H(2)O.
Cofactor:
COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
Cross Reference Drug Bank:
DB08868
Gene Ontology Go:
apical plasma membrane
cytoplasm
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
alkane 1-monooxygenase activity
arachidonic acid epoxygenase activity
aromatase activity
heme binding
iron ion binding
leukotriene-B4 20-monooxygenase activity
arachidonic acid metabolic process
drug metabolic process
epoxygenase P450 pathway
leukotriene B4 catabolic process
long-chain fatty acid metabolic process
oxidation-reduction process
pressure natriuresis
renal water homeostasis
small molecule metabolic process
sodium ion homeostasis
very long-chain fatty acid metabolic process
vitamin E metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
arachidonic acid metabolic process
drug metabolic process
epoxygenase P450 pathway
leukotriene B4 catabolic process
long-chain fatty acid metabolic process
oxidation-reduction process
pressure natriuresis
renal water homeostasis
small molecule metabolic process
sodium ion homeostasis
very long-chain fatty acid metabolic process
vitamin E metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
alkane 1-monooxygenase activity
arachidonic acid epoxygenase activity
aromatase activity
heme binding
iron ion binding
leukotriene-B4 20-monooxygenase activity
Gene Ontology Cellular Component:
apical plasma membrane
cytoplasm
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
Keywords:
Alternative splicing
Complete proteome
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
Oxidoreductase
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix

Publication

PubMed ID:
11162607 11162645 12975309 16303743 17974005 15057824