Names & Taxonomy
- Uniprot ID:
- Q9HCS2
- Entry Name:
- CP4FC_HUMAN
- Status:
- reviewed
- Protein Names:
- Cytochrome P450 4F12 (EC 1.14.14.1) (CYPIVF12)
- Gene Names:
- CYP4F12 UNQ568/PRO1129
- Gene Names Orf:
- UNQ568/PRO1129
- Gene Names Primary:
- CYP4F12
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 524
- Sequence:
- MSLLSLPWLGLRPVATSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLGLITPTEEGLKNSTQMSATYSQGFTIWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSCLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRVEPLNVSLQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane
Function
- Function:
- Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine.
- Catalytic Activity:
- RH + + O(2) = ROH + + H(2)O.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Cross Reference Drug Bank:
- DB08868
- Gene Ontology Go:
- apical plasma membrane
cytoplasm
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
alkane 1-monooxygenase activity
arachidonic acid epoxygenase activity
aromatase activity
heme binding
iron ion binding
leukotriene-B4 20-monooxygenase activity
arachidonic acid metabolic process
drug metabolic process
epoxygenase P450 pathway
leukotriene B4 catabolic process
long-chain fatty acid metabolic process
oxidation-reduction process
pressure natriuresis
renal water homeostasis
small molecule metabolic process
sodium ion homeostasis
very long-chain fatty acid metabolic process
vitamin E metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- arachidonic acid metabolic process
drug metabolic process
epoxygenase P450 pathway
leukotriene B4 catabolic process
long-chain fatty acid metabolic process
oxidation-reduction process
pressure natriuresis
renal water homeostasis
small molecule metabolic process
sodium ion homeostasis
very long-chain fatty acid metabolic process
vitamin E metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- alkane 1-monooxygenase activity
arachidonic acid epoxygenase activity
aromatase activity
heme binding
iron ion binding
leukotriene-B4 20-monooxygenase activity - Gene Ontology Cellular Component:
- apical plasma membrane
cytoplasm
endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle - Keywords:
- Alternative splicing
Complete proteome
Endoplasmic reticulum
Heme
Iron
Membrane
Metal-binding
Microsome
Monooxygenase
Oxidoreductase
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix