Names & Taxonomy
- Uniprot ID:
- Q9HCR9
- Entry Name:
- PDE11_HUMAN
- Status:
- reviewed
- Protein Names:
- Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP and cGMP phosphodiesterase 11A)
- Gene Names:
- PDE11A
- Gene Names Primary:
- PDE11A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 933
- Sequence:
- MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSSLAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKELRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRVNLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytosol
Function
- Function:
- Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
- Catalytic Activity:
- Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.; Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
- Cofactor:
- COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=3.0 uM for cAMP (isoform 1)
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by 3-isobutyl-1-methylxanthine (IBMX), zaprinast and dipyridamole. cGMP acts as an allosteric activator. Weakly inhibited by Sildenafil (Viagra) and Tadalafil (Cialis); however, the fact that the protein is probably absent from testis, suggests that it is not biologically relevant and is not related with erectile dysfunction.
- Active Site:
- ACT_SITE 664 664 Proton donor.
- Cross Reference Drug Bank:
- DB00201 DB00820
- Gene Ontology Go:
- cytosol
perikaryon
3',5'-cyclic-GMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
cAMP binding
cGMP binding
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
cyclic-nucleotide phosphodiesterase activity
metal ion binding
blood coagulation
cAMP catabolic process
cGMP catabolic process
signal transduction - Gene Ontology Biological Process:
- blood coagulation
cAMP catabolic process
cGMP catabolic process
signal transduction - Gene Ontology Molecular Function:
- 3',5'-cyclic-GMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
cAMP binding
cGMP binding
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
cyclic-nucleotide phosphodiesterase activity
metal ion binding - Gene Ontology Cellular Component:
- cytosol
perikaryon - Keywords:
- Allosteric enzyme
Alternative splicing
Complete proteome
Cushing syndrome
Cytoplasm
Hydrolase
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
cAMP
cGMP