Names & Taxonomy

Uniprot ID:
Q9HCR9
Entry Name:
PDE11_HUMAN
Status:
reviewed
Protein Names:
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.35) (EC 3.1.4.53) (cAMP and cGMP phosphodiesterase 11A)
Gene Names:
PDE11A
Gene Names Primary:
PDE11A
Organism:
Homo sapiens (Human)

Structure

Length:
933
Sequence:
MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSSLAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKELRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRVNLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytosol

Function

Function:
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively.
Catalytic Activity:
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.; Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
Cofactor:
COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=3.0 uM for cAMP (isoform 1)
Enzyme Regulation:
ENZYME REGULATION: Inhibited by 3-isobutyl-1-methylxanthine (IBMX), zaprinast and dipyridamole. cGMP acts as an allosteric activator. Weakly inhibited by Sildenafil (Viagra) and Tadalafil (Cialis); however, the fact that the protein is probably absent from testis, suggests that it is not biologically relevant and is not related with erectile dysfunction.
Active Site:
ACT_SITE 664 664 Proton donor.
Cross Reference Drug Bank:
DB00201 DB00820
Gene Ontology Go:
cytosol
perikaryon
3',5'-cyclic-GMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
cAMP binding
cGMP binding
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
cyclic-nucleotide phosphodiesterase activity
metal ion binding
blood coagulation
cAMP catabolic process
cGMP catabolic process
signal transduction
Gene Ontology Biological Process:
blood coagulation
cAMP catabolic process
cGMP catabolic process
signal transduction
Gene Ontology Molecular Function:
3',5'-cyclic-GMP phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
cAMP binding
cGMP binding
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
cyclic-nucleotide phosphodiesterase activity
metal ion binding
Gene Ontology Cellular Component:
cytosol
perikaryon
Keywords:
Allosteric enzyme
Alternative splicing
Complete proteome
Cushing syndrome
Cytoplasm
Hydrolase
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Repeat
cAMP
cGMP

Publication

PubMed ID:
10906126 10725373 11050148 11121118 15815621 15489334 15800651 16079899 16330539 16767104 19690332