Names & Taxonomy
- Uniprot ID:
- Q9HCP0
- Entry Name:
- KC1G1_HUMAN
- Status:
- reviewed
- Protein Names:
- Casein kinase I isoform gamma-1 (CKI-gamma 1) (EC 2.7.11.1)
- Gene Names:
- CSNK1G1
- Gene Names Primary:
- CSNK1G1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 422
- Sequence:
- MDHPSREKDERQRTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRPSQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKCCCFFKRKRKKTAQRHK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Enzyme Regulation:
- ENZYME REGULATION: Repressed by 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine (DB08325).
- Active Site:
- ACT_SITE 164 164 Proton acceptor.
- Gene Ontology Go:
- cytoplasm
ATP binding
magnesium ion binding
peptide binding
protein serine/threonine kinase activity
peptidyl-serine phosphorylation
protein autophosphorylation
Wnt signaling pathway - Gene Ontology Biological Process:
- peptidyl-serine phosphorylation
protein autophosphorylation
Wnt signaling pathway - Gene Ontology Molecular Function:
- ATP binding
magnesium ion binding
peptide binding
protein serine/threonine kinase activity - Gene Ontology Cellular Component:
- cytoplasm
- Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Complete proteome
Cytoplasm
Kinase
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase
Wnt signaling pathway - Interacts With:
- Q8TAP6; P60409