Names & Taxonomy
- Uniprot ID:
- Q9HBW0
- Entry Name:
- LPAR2_HUMAN
- Status:
- reviewed
- Protein Names:
- Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4)
- Gene Names:
- LPAR2 EDG4 LPA2
- Gene Names Primary:
- LPAR2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 351
- Sequence:
- MVIMGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell surface
Function
- Function:
- Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.
- Gene Ontology Go:
- cell surface
integral component of plasma membrane
plasma membrane
G-protein coupled receptor activity
lipid binding
lysophosphatidic acid receptor activity
activation of phospholipase C activity
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration - Gene Ontology Biological Process:
- activation of phospholipase C activity
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
lipid binding
lysophosphatidic acid receptor activity - Gene Ontology Cellular Component:
- cell surface
integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Cell membrane
Complete proteome
G-protein coupled receptor
Glycoprotein
Lipoprotein
Membrane
Palmitate
Receptor
Reference proteome
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- P13569; Q15599