Names & Taxonomy
- Uniprot ID:
- Q9HAW7
- Entry Name:
- UD17_HUMAN
- Status:
- reviewed
- Protein Names:
- UDP-glucuronosyltransferase 1-7 (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-G) (UGT-1G) (UGT1G) (UDP-glucuronosyltransferase 1A7)
- Gene Names:
- UGT1A7 GNT1 UGT1
- Gene Names Primary:
- UGT1A7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 530
- Sequence:
- MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLFFSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEGAQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Microsome. Endoplasmic reticulum membrane
Function
- Function:
- UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1.
- Catalytic Activity:
- UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
- Cross Reference Drug Bank:
- DB00688 DB01024
- Gene Ontology Go:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane
drug binding
enzyme binding
enzyme inhibitor activity
glucuronosyltransferase activity
protein heterodimerization activity
protein homodimerization activity
protein kinase C binding
retinoic acid binding
cellular glucuronidation
coumarin metabolic process
drug metabolic process
excretion
fatty acid metabolic process
flavone metabolic process
flavonoid biosynthetic process
flavonoid glucuronidation
negative regulation of catalytic activity
negative regulation of cellular glucuronidation
negative regulation of fatty acid metabolic process
negative regulation of glucuronosyltransferase activity
retinoic acid metabolic process
xenobiotic glucuronidation - Gene Ontology Biological Process:
- cellular glucuronidation
coumarin metabolic process
drug metabolic process
excretion
fatty acid metabolic process
flavone metabolic process
flavonoid biosynthetic process
flavonoid glucuronidation
negative regulation of catalytic activity
negative regulation of cellular glucuronidation
negative regulation of fatty acid metabolic process
negative regulation of glucuronosyltransferase activity
retinoic acid metabolic process
xenobiotic glucuronidation - Gene Ontology Molecular Function:
- drug binding
enzyme binding
enzyme inhibitor activity
glucuronosyltransferase activity
protein heterodimerization activity
protein homodimerization activity
protein kinase C binding
retinoic acid binding - Gene Ontology Cellular Component:
- endoplasmic reticulum
endoplasmic reticulum membrane
integral component of membrane - Keywords:
- Alternative splicing
Complete proteome
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Membrane
Microsome
Polymorphism
Reference proteome
Signal
Transferase
Transmembrane
Transmembrane helix