Names & Taxonomy
- Uniprot ID:
- Q9HAS3
- Entry Name:
- S28A3_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 28 member 3 (Concentrative Na(+)-nucleoside cotransporter 3) (CNT 3) (hCNT3)
- Gene Names:
- SLC28A3 CNT3
- Gene Names Primary:
- SLC28A3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 691
- Sequence:
- MELRSTAAPRAEGYSNVGFQNEENFLENENTSGNNSIRSRAVQSREHTNTKQDEEQVTVEQDSPRNREHMEDDDEEMQQKGCLERRYDTVCGFCRKHKTTLRHIIWGILLAGYLVMVISACVLNFHRALPLFVITVAAIFFVVWDHLMAKYEHRIDEMLSPGRRLLNSHWFWLKWVIWSSLVLAVIFWLAFDTAKLGQQQLVSFGGLIMYIVLLFLFSKYPTRVYWRPVLWGIGLQFLLGLLILRTDPGFIAFDWLGRQVQTFLEYTDAGASFVFGEKYKDHFFAFKVLPIVVFFSTVMSMLYYLGLMQWIIRKVGWIMLVTTGSSPIESVVASGNIFVGQTESPLLVRPYLPYITKSELHAIMTAGFSTIAGSVLGAYISFGVPSSHLLTASVMSAPASLAAAKLFWPETEKPKITLKNAMKMESGDSGNLLEAATQGASSSISLVANIAVNLIAFLALLSFMNSALSWFGNMFDYPQLSFELICSYIFMPFSFMMGVEWQDSFMVARLIGYKTFFNEFVAYEHLSKWIHLRKEGGPKFVNGVQQYISIRSEIIATYALCGFANIGSLGIVIGGLTSMAPSRKRDIASGAVRALIAGTVACFMTACIAGILSSTPVDINCHHVLENAFNSTFPGNTTKVIACCQSLLSSTVAKGPGEVIPGGNHSLYSLKGCCTLLNPSTFNCNGISNTF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane; Multi-pass membrane protein.; Isoform 2: Endoplasmic reticulum membrane; Multi-pass membrane protein.
Function
- Function:
- Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine.
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=21.6 uM for uridine
- Cross Reference Drug Bank:
- DB00640 DB00242 DB01073 DB00441 DB01033 DB00811
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of plasma membrane
plasma membrane
purine-specific nucleoside:sodium symporter activity
pyrimidine- and adenine-specific:sodium symporter activity
pyrimidine nucleoside transport
retina homeostasis
transmembrane transport - Gene Ontology Biological Process:
- pyrimidine nucleoside transport
retina homeostasis
transmembrane transport - Gene Ontology Molecular Function:
- purine-specific nucleoside:sodium symporter activity
pyrimidine- and adenine-specific:sodium symporter activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of plasma membrane
plasma membrane - Keywords:
- Alternative splicing
Cell membrane
Complete proteome
Endoplasmic reticulum
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix