Names & Taxonomy
- Uniprot ID:
- Q9HAB3
- Entry Name:
- S52A2_HUMAN
- Status:
- reviewed
- Protein Names:
- Solute carrier family 52, riboflavin transporter, member 2 (Porcine endogenous retrovirus A receptor 1) (PERV-A receptor 1) (Protein GPR172A) (Riboflavin transporter 3) (hRFT3)
- Gene Names:
- SLC52A2 GPR172A PAR1 RFT3
- Gene Names Primary:
- SLC52A2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 445
- Sequence:
- MAAPTPARPVLTHLLVALFGMGSWAAVNGIWVELPVVVKELPEGWSLPSYVSVLVALGNLGLLVVTLWRRLAPGKDEQVPIRVVQVLGMVGTALLASLWHHVAPVAGQLHSVAFLALAFVLALACCASNVTFLPFLSHLPPRFLRSFFLGQGLSALLPCVLALVQGVGRLECPPAPINGTPGPPLDFLERFPASTFFWALTALLVASAAAFQGLLLLLPPPPSVPTGELGSGLQVGAPGAEEEVEESSPLQEPPSQAAGTTPGPDPKAYQLLSARSACLLGLLAATNALTNGVLPAVQSFSCLPYGRLAYHLAVVLGSAANPLACFLAMGVLCRSLAGLGGLSLLGVFCGGYLMALAVLSPCPPLVGTSAGVVLVVLSWVLCLGVFSYVKVAASSLLHGGGRPALLAAGVAIQVGSLLGAVAMFPPTSIYHVFHSRKDCADPCDS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Riboflavin transporter. Riboflavin transport is Na(+)-independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).
- Kinetics:
- BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.33 uM for riboflavin
- Cross Reference Drug Bank:
- DB01440
- Gene Ontology Go:
- integral component of plasma membrane
riboflavin transporter activity
virus receptor activity
riboflavin transport - Gene Ontology Biological Process:
- riboflavin transport
- Gene Ontology Molecular Function:
- riboflavin transporter activity
virus receptor activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
- Keywords:
- Cell membrane
Complete proteome
Deafness
Disease mutation
Host cell receptor for virus entry
Membrane
Receptor
Reference proteome
Transmembrane
Transmembrane helix
Transport - Interacts With:
- Q9UJX2