Names & Taxonomy

Uniprot ID:
Q9HAB3
Entry Name:
S52A2_HUMAN
Status:
reviewed
Protein Names:
Solute carrier family 52, riboflavin transporter, member 2 (Porcine endogenous retrovirus A receptor 1) (PERV-A receptor 1) (Protein GPR172A) (Riboflavin transporter 3) (hRFT3)
Gene Names:
SLC52A2 GPR172A PAR1 RFT3
Gene Names Primary:
SLC52A2
Organism:
Homo sapiens (Human)

Structure

Length:
445
Sequence:
MAAPTPARPVLTHLLVALFGMGSWAAVNGIWVELPVVVKELPEGWSLPSYVSVLVALGNLGLLVVTLWRRLAPGKDEQVPIRVVQVLGMVGTALLASLWHHVAPVAGQLHSVAFLALAFVLALACCASNVTFLPFLSHLPPRFLRSFFLGQGLSALLPCVLALVQGVGRLECPPAPINGTPGPPLDFLERFPASTFFWALTALLVASAAAFQGLLLLLPPPPSVPTGELGSGLQVGAPGAEEEVEESSPLQEPPSQAAGTTPGPDPKAYQLLSARSACLLGLLAATNALTNGVLPAVQSFSCLPYGRLAYHLAVVLGSAANPLACFLAMGVLCRSLAGLGGLSLLGVFCGGYLMALAVLSPCPPLVGTSAGVVLVVLSWVLCLGVFSYVKVAASSLLHGGGRPALLAAGVAIQVGSLLGAVAMFPPTSIYHVFHSRKDCADPCDS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Riboflavin transporter. Riboflavin transport is Na(+)-independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).
Kinetics:
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.33 uM for riboflavin
Cross Reference Drug Bank:
DB01440
Gene Ontology Go:
integral component of plasma membrane
riboflavin transporter activity
virus receptor activity
riboflavin transport
Gene Ontology Biological Process:
riboflavin transport
Gene Ontology Molecular Function:
riboflavin transporter activity
virus receptor activity
Gene Ontology Cellular Component:
integral component of plasma membrane
Keywords:
Cell membrane
Complete proteome
Deafness
Disease mutation
Host cell receptor for virus entry
Membrane
Receptor
Reference proteome
Transmembrane
Transmembrane helix
Transport
Interacts With:
Q9UJX2

Publication

PubMed ID:
12740431 20463145 14702039 16421571 15489334 19307586 22740598