Names & Taxonomy
- Uniprot ID:
- Q9HA77
- Entry Name:
- SYCM_HUMAN
- Status:
- reviewed
- Protein Names:
- Probable cysteine--tRNA ligase, mitochondrial (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS)
- Gene Names:
- CARS2 OK/SW-cl.10
- Gene Names Orf:
- OK/SW-cl.10
- Gene Names Primary:
- CARS2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 564
- Sequence:
- MLRTTRGPGLGPPLLQAALGLGRAGWHWPAGRAASGGRGRAWLQPTGRETGVQVYNSLTGRKEPLIVAHAEAASWYSCGPTVYDHAHLGHACSYVRFDIIRRILTKVFGCSIVMVMGITDVDDKIIKRANEMNISPASLASLYEEDFKQDMAALKVLPPTVYLRVTENIPQIISFIEGIIARGNAYSTAKGNVYFDLKSRGDKYGKLVGVVPGPVGEPADSDKRHASDFALWKAAKPQEVFWASPWGPGRPGWHIECSAIASMVFGSQLDIHSGGIDLAFPHHENEIAQCEVFHQCEQWGNYFLHSGHLHAKGKEEKMSKSLKNYITIKDFLKTFSPDVFRFFCLRSSYRSAIDYSDSAMLQAQQLLLGLGSFLEDARAYMKGQLACGSVREAMLWERLSSTKRAVKAALADDFDTPRVVDAILGLAHHGNGQLRASLKEPEGPRSPAVFGAIISYFEQFFETVGISLANQQYVSGDGSEATLHGVVDELVRFRQKVRQFALAMPEATGDARRQQLLERQPLLEACDTLRRGLTAHGINIKDRSSTTSTWELLDQRTKDQKSAG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion matrix
Function
- Catalytic Activity:
- ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Cross Reference Drug Bank:
- DB00151
- Gene Ontology Go:
- cytosol
mitochondrial matrix
ATP binding
cysteine-tRNA ligase activity
metal ion binding
cysteinyl-tRNA aminoacylation
gene expression
tRNA aminoacylation for protein translation - Gene Ontology Biological Process:
- cysteinyl-tRNA aminoacylation
gene expression
tRNA aminoacylation for protein translation - Gene Ontology Molecular Function:
- ATP binding
cysteine-tRNA ligase activity
metal ion binding - Gene Ontology Cellular Component:
- cytosol
mitochondrial matrix - Keywords:
- ATP-binding
Aminoacyl-tRNA synthetase
Complete proteome
Disease mutation
Ligase
Metal-binding
Mitochondrion
Nucleotide-binding
Polymorphism
Protein biosynthesis
Reference proteome
Transit peptide
Zinc