Names & Taxonomy
- Uniprot ID:
- Q9H4Y5
- Entry Name:
- GSTO2_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutathione S-transferase omega-2 (GSTO-2) (EC 2.5.1.18) (Glutathione S-transferase omega 2-2) (GSTO 2-2) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2)
- Gene Names:
- GSTO2
- Gene Names Primary:
- GSTO2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 243
- Sequence:
- MSGDATRTLGKGSQPPGPVPEGLIRIYSMRFCPYSHRTRLVLKAKDIRHEVVNINLRNKPEWYYTKHPFGHIPVLETSQCQLIYESVIACEYLDDAYPGRKLFPYDPYERARQKMLLELFCKVPHLTKECLVALRCGRECTNLKAALRQEFSNLEEILEYQNTTFFGGTCISMIDYLLWPWFERLDVYGILDCVSHTPALRLWISAMKWDPTVCALLMDKSIFQGFLNLYFQNNPNAFDFGLC
- Proteomes:
- UP000005640
Function
- Function:
- Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA).
- Catalytic Activity:
- RX + glutathione = HX + R-S-glutathione.
- Active Site:
- ACT_SITE 32 32 Nucleophile.
- Cross Reference Drug Bank:
- DB00143
- Gene Ontology Go:
- cytoplasm
cytosol
extracellular exosome
glutathione dehydrogenase (ascorbate) activity
glutathione transferase activity
methylarsonate reductase activity
oxidoreductase activity
cellular oxidant detoxification
cellular response to arsenic-containing substance
glutathione derivative biosynthetic process
glutathione metabolic process
L-ascorbic acid metabolic process
oxidation-reduction process
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular oxidant detoxification
cellular response to arsenic-containing substance
glutathione derivative biosynthetic process
glutathione metabolic process
L-ascorbic acid metabolic process
oxidation-reduction process
small molecule metabolic process
vitamin metabolic process
water-soluble vitamin metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- glutathione dehydrogenase (ascorbate) activity
glutathione transferase activity
methylarsonate reductase activity
oxidoreductase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol
extracellular exosome - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Oxidoreductase
Polymorphism
Reference proteome
Transferase - Interacts With:
- Q9H6H2; P05549