Names & Taxonomy
- Uniprot ID:
- Q9H461
- Entry Name:
- FZD8_HUMAN
- Status:
- reviewed
- Protein Names:
- Frizzled-8 (Fz-8) (hFz8)
- Gene Names:
- FZD8
- Gene Names Primary:
- FZD8
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 694
- Sequence:
- MEWGYLLEVTSLLAALALLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPPGEQPPSGSGHGRPPGARPPHRGGGRGGGGGDAAAPPARGGGGGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAGAGAAGAGAGGPGGRGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQDGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRSLCTRCCWASKGAAVGGGAGATAAGGGGGPGGGGGGGPGGGGGPGGGGGSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein. Golgi apparatus
Function
- Function:
- Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
- Gene Ontology Go:
- Golgi apparatus
integral component of membrane
Wnt-Frizzled-LRP5/6 complex
G-protein coupled receptor activity
PDZ domain binding
ubiquitin protein ligase binding
Wnt-activated receptor activity
Wnt-protein binding
angiogenesis
canonical Wnt signaling pathway
negative regulation of transcription from RNA polymerase II promoter
neuron differentiation
non-canonical Wnt signaling pathway
positive regulation of JUN kinase activity
positive regulation of transcription from RNA polymerase II promoter
T cell differentiation in thymus - Gene Ontology Biological Process:
- angiogenesis
canonical Wnt signaling pathway
negative regulation of transcription from RNA polymerase II promoter
neuron differentiation
non-canonical Wnt signaling pathway
positive regulation of JUN kinase activity
positive regulation of transcription from RNA polymerase II promoter
T cell differentiation in thymus - Gene Ontology Molecular Function:
- G-protein coupled receptor activity
PDZ domain binding
ubiquitin protein ligase binding
Wnt-activated receptor activity
Wnt-protein binding - Gene Ontology Cellular Component:
- Golgi apparatus
integral component of membrane
Wnt-Frizzled-LRP5/6 complex - Keywords:
- Cell membrane
Complete proteome
Developmental protein
Disulfide bond
G-protein coupled receptor
Glycoprotein
Golgi apparatus
Membrane
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix
Ubl conjugation
Wnt signaling pathway - Interacts With:
- P98086; P56704