Names & Taxonomy
- Uniprot ID:
- Q9H3H5
- Entry Name:
- GPT_HUMAN
- Status:
- reviewed
- Protein Names:
- UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.15) (GlcNAc-1-P transferase) (G1PT) (GPT) (N-acetylglucosamine-1-phosphate transferase)
- Gene Names:
- DPAGT1 DPAGT2
- Gene Names Primary:
- DPAGT1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 408
- Sequence:
- MWAFSELPMPLLINLIVSLLGFVATVTLIPAFRGHFIAARLCGQDLNKTSRQQIPESQGVISGAVFLIILFCFIPFPFLNCFVKEQCKAFPHHEFVALIGALLAICCMIFLGFADDVLNLRWRHKLLLPTAASLPLLMVYFTNFGNTTIVVPKPFRPILGLHLDLGILYYVYMGLLAVFCTNAINILAGINGLEAGQSLVISASIIVFNLVELEGDCRDDHVFSLYFMIPFFFTTLGLLYHNWYPSRVFVGDTFCYFAGMTFAVVGILGHFSKTMLLFFMPQVFNFLYSLPQLLHIIPCPRHRIPRLNIKTGKLEMSYSKFKTKSLSFLGTFILKVAESLQLVTVHQSETEDGEFTECNNMTLINLLLKVLGPIHERNLTLLLLLLQILGSAITFSIRYQLVRLFYDV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Multi-pass membrane protein.
Function
- Function:
- Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides.
- Pathway:
- Protein modification; protein glycosylation.
- Catalytic Activity:
- UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol.
- Gene Ontology Go:
- endoplasmic reticulum membrane
integral component of endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane
phospho-N-acetylmuramoyl-pentapeptide-transferase activity
transferase activity, transferring glycosyl groups
UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
cellular protein metabolic process
dolichol biosynthetic process
dolichol-linked oligosaccharide biosynthetic process
post-translational protein modification
protein N-linked glycosylation
protein N-linked glycosylation via asparagine
protein oligomerization
UDP-N-acetylglucosamine metabolic process - Gene Ontology Biological Process:
- cellular protein metabolic process
dolichol biosynthetic process
dolichol-linked oligosaccharide biosynthetic process
post-translational protein modification
protein N-linked glycosylation
protein N-linked glycosylation via asparagine
protein oligomerization
UDP-N-acetylglucosamine metabolic process - Gene Ontology Molecular Function:
- phospho-N-acetylmuramoyl-pentapeptide-transferase activity
transferase activity, transferring glycosyl groups
UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity - Gene Ontology Cellular Component:
- endoplasmic reticulum membrane
integral component of endoplasmic reticulum membrane
integral component of membrane
intracellular membrane-bounded organelle
membrane - Keywords:
- Alternative splicing
Complete proteome
Congenital disorder of glycosylation
Congenital myasthenic syndrome
Disease mutation
Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Membrane
Polymorphism
Reference proteome
Transferase
Transmembrane
Transmembrane helix