Names & Taxonomy
- Uniprot ID:
- Q9H306
- Entry Name:
- MMP27_HUMAN
- Status:
- reviewed
- Protein Names:
- Matrix metalloproteinase-27 (MMP-27) (EC 3.4.24.-)
- Gene Names:
- MMP27 UNQ2503/PRO5992
- Gene Names Orf:
- UNQ2503/PRO5992
- Gene Names Primary:
- MMP27
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 513
- Sequence:
- MKRLLLLFLFFITFSSAFPLVRMTENEENMQLAQAYLNQFYSLEIEGNHLVQSKNRSLIDDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTLPGWRKYNLTYRIINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLGVLGHAFPPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKYPLSQDDINGIQSIYGGLPKEPAKPKEPTIPHACDPDLTFDAITTFRREVMFFKGRHLWRIYYDITDVEFELIASFWPSLPADLQAAYENPRDKILVFKDENFWMIRGYAVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGISIRVDAAFQYKGFFFFSRGSKQFEYDIKTKNITRIMRTNTWFQCKEPKNSSFGFDINKEKAHSGGIKILYHKSLSLFIFGIVHLLKNTSIYQ
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Endoplasmic reticulum membrane; Peripheral membrane protein
Function
- Function:
- Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens.
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Active Site:
- ACT_SITE 217 217
- Cross Reference Drug Bank:
- DB00786
- Gene Ontology Go:
- extracellular matrix
extrinsic component of endoplasmic reticulum membrane
calcium ion binding
metalloendopeptidase activity
zinc ion binding
collagen catabolic process - Gene Ontology Biological Process:
- collagen catabolic process
- Gene Ontology Molecular Function:
- calcium ion binding
metalloendopeptidase activity
zinc ion binding - Gene Ontology Cellular Component:
- extracellular matrix
extrinsic component of endoplasmic reticulum membrane - Keywords:
- Calcium
Collagen degradation
Complete proteome
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Hydrolase
Membrane
Metal-binding
Metalloprotease
Polymorphism
Protease
Reference proteome
Repeat
Signal
Zinc
Zymogen