Names & Taxonomy
- Uniprot ID:
- Q9H2S1
- Entry Name:
- KCNN2_HUMAN
- Status:
- reviewed
- Protein Names:
- Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2)
- Gene Names:
- KCNN2
- Gene Names Primary:
- KCNN2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 579
- Sequence:
- MSSCRYNGGVMRPLSNLSASRRNLHEMDSEAQPLQPPASVGGGGGASSPSAAAAAAAAVSSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIEAQMESYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Multi-pass membrane protein.
- Intramembrane:
- INTRAMEM 345 365 Pore-forming; Name=Segment H5.
Function
- Function:
- Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.
- Cross Reference Drug Bank:
- DB01110 DB00721
- Gene Ontology Go:
- cell surface
dendritic spine
integral component of membrane
neuronal cell body
plasma membrane
smooth endoplasmic reticulum
T-tubule
Z disc
alpha-actinin binding
calcium-activated potassium channel activity
calmodulin binding
protein domain specific binding
protein homodimerization activity
small conductance calcium-activated potassium channel activity
potassium ion transmembrane transport
potassium ion transport
regulation of potassium ion transmembrane transport
synaptic transmission - Gene Ontology Biological Process:
- potassium ion transmembrane transport
potassium ion transport
regulation of potassium ion transmembrane transport
synaptic transmission - Gene Ontology Molecular Function:
- alpha-actinin binding
calcium-activated potassium channel activity
calmodulin binding
protein domain specific binding
protein homodimerization activity
small conductance calcium-activated potassium channel activity - Gene Ontology Cellular Component:
- cell surface
dendritic spine
integral component of membrane
neuronal cell body
plasma membrane
smooth endoplasmic reticulum
T-tubule
Z disc - Keywords:
- Alternative splicing
Calmodulin-binding
Complete proteome
Ion channel
Ion transport
Membrane
Phosphoprotein
Reference proteome
Transmembrane
Transmembrane helix
Transport