Names & Taxonomy
- Uniprot ID:
- Q9H2G2
- Entry Name:
- SLK_HUMAN
- Status:
- reviewed
- Protein Names:
- STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2)
- Gene Names:
- SLK KIAA0204 STK2
- Gene Names Primary:
- SLK
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1235
- Sequence:
- MSFFNFRKIFKLGSEKKKKQYEHVKRDLNPEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVTEEVEDGKEEDEEEETENSLPIPASKRASSDLSIASSEEDKLSQNACILESVSEKTERSNSEDKLNSKILNEKPTTDEPEKAVEDINEHITDAQLEAMTELHDRTAVIKENEREKRPKLENLPDTEDQETVDINSVSEGKENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKSEEIKDTILQTVDLVSQETGEKEANIQAVDSEVGLTKEDTQEKLGEDDKTQKDVISNTSDVIGTCEAADVAQKVDEDSAEDTQSNDGKEVVEVGQKLINKPMVGPEAGGTKEVPIKEIVEMNEIEEGKNKEQAINSSENIMDINEEPGTTEGEEITESSSTEEMEVRSVVADTDQKALGSEVQDASKVTTQIDKEKKEIPVSIKKEPEVTVVSQPTEPQPVLIPSININSDSGENKEEIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDSGSISLQETRRQKKTLKKTRKFIVDGVEVSVTTSKIVTDSDSKTEELRFLRRQELRELRFLQKEEQRAQQQLNSKLQQQREQIFRRFEQEMMSKKRQYDQEIENLEKQQKQTIERLEQEHTNRLRDEAKRIKGEQEKELSKFQNMLKNRKKEVINEVEKAPKELRKELMKRRKEELAQSQHAQEQEFVQKQQQELDGSLKKIIQQQKAELANIERECLNNKQQLMRAREAAIWELEERHLQEKHQLLKQQLKDQYFMQRHQLLKRHEKETEQMQRYNQRLIEELKNRQTQERARLPKIQRSEAKTRMAMFKKSLRINSTATPDQDRDKIKQFAAQEEKRQKNERMAQHQKHENQMRDLQLQCEANVRELHQLQNEKCHLLVEHETQKLKELDEEHSQELKEWREKLRPRKKTLEEEFARKLQEQEVFFKMTGESECLNPSTQSRISKFYPIPSLHSTGS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Mediates apoptosis and actin stress fiber dissolution.
- Catalytic Activity:
- ATP + a protein = ADP + a phosphoprotein.
- Active Site:
- ACT_SITE 155 155 Proton acceptor.
- Gene Ontology Go:
- cell leading edge
cytoplasm
extracellular exosome
ATP binding
identical protein binding
protein homodimerization activity
protein serine/threonine kinase activity
activation of protein kinase activity
apoptotic process
cytoplasmic microtubule organization
protein autophosphorylation
regulation of apoptotic process
regulation of cell migration
regulation of focal adhesion assembly
regulation of mitotic cell cycle
signal transduction by protein phosphorylation
stress-activated protein kinase signaling cascade - Gene Ontology Biological Process:
- activation of protein kinase activity
apoptotic process
cytoplasmic microtubule organization
protein autophosphorylation
regulation of apoptotic process
regulation of cell migration
regulation of focal adhesion assembly
regulation of mitotic cell cycle
signal transduction by protein phosphorylation
stress-activated protein kinase signaling cascade - Gene Ontology Molecular Function:
- ATP binding
identical protein binding
protein homodimerization activity
protein serine/threonine kinase activity - Gene Ontology Cellular Component:
- cell leading edge
cytoplasm
extracellular exosome - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Apoptosis
Coiled coil
Complete proteome
Cytoplasm
Kinase
Nucleotide-binding
Phosphoprotein
Polymorphism
Reference proteome
Serine/threonine-protein kinase
Transferase - Interacts With:
- Itself